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1
Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.通过增加一个不连锁基因座的剂量来抑制黑腹果蝇的致死三体表型。
Genetics. 1993 May;134(1):243-9. doi: 10.1093/genetics/134.1.243.
2
The Triplo-lethal locus of Drosophila: reexamination of mutants and discovery of a second-site suppressor.果蝇的三倍体致死基因座：突变体的重新研究及一个第二位点抑制因子的发现。
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3
The unusual spectrum of mutations induced by hybrid dysgenesis at the Triplo-lethal locus of Drosophila melanogaster.果蝇黑腹果蝇三倍体致死位点杂交不育诱导的异常突变谱。
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4
Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia.黑腹果蝇三倍体致死基因座的表型及其高氧抑制作用。
Genet Res. 2003 Dec;82(3):163-70. doi: 10.1017/s001667230300644x.
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Segmental aneuploidy and the genetic gross structure of the Drosophila genome.节段性非整倍体与果蝇基因组的遗传总体结构。
Genetics. 1972 May;71(1):157-84. doi: 10.1093/genetics/71.1.157.
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A recombinational hotspot at the triplo-lethal locus of Drosophila melanogaster.果蝇三倍体致死位点处的一个重组热点。
Genetics. 1989 Jun;122(2):397-401. doi: 10.1093/genetics/122.2.397.
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A mutational analysis of the triplo-lethal region of Drosophila melanogaster.黑腹果蝇三倍体致死区域的突变分析。
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A family of genes clustered at the Triplo-lethal locus of Drosophila melanogaster has an unusual evolutionary history and significant synteny with Anopheles gambiae.在黑腹果蝇三倍体致死位点聚集的一个基因家族具有不同寻常的进化史，并且与冈比亚按蚊有显著的同线性。
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A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila.一个与果蝇三倍体致死基因座紧密连锁的新型RNA解旋酶基因。
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An increase in the X-linked lethal mutation rate associated with an unstable locus in Drosophila melanogaster.与黑腹果蝇中一个不稳定基因座相关的X连锁致死突变率的增加。
Genetics. 1981 Jun;98(2):291-302. doi: 10.1093/genetics/98.2.291.

引用本文的文献

1
A family of genes clustered at the Triplo-lethal locus of Drosophila melanogaster has an unusual evolutionary history and significant synteny with Anopheles gambiae.在黑腹果蝇三倍体致死位点聚集的一个基因家族具有不同寻常的进化史，并且与冈比亚按蚊有显著的同线性。
Genetics. 2003 Oct;165(2):613-21. doi: 10.1093/genetics/165.2.613.
2
The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.果蝇16F基因簇的单倍体致死区域：结构与功能
Genetics. 1999 Jan;151(1):163-75. doi: 10.1093/genetics/151.1.163.
3
A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function.对果蝇X染色体进行遗传筛选，以寻找能改变变形功能的突变。
Genetics. 1998 Dec;150(4):1497-511. doi: 10.1093/genetics/150.4.1497.

本文引用的文献

1
Mutational Events in the Triplo- and Haplo-Lethal Region (83de) of the DROSOPHILA MELANOGASTER Genome.果蝇基因组三倍体和半倍体致死区（83de）的突变事件。
Genetics. 1980 Jun;95(2):355-66. doi: 10.1093/genetics/95.2.355.
2
A study of enzyme activities in a dosage series of the long arm of chromosome one in maize.玉米第一号染色体长臂剂量系列的酶活性研究。
Genetics. 1979 Aug;92(4):1211-29. doi: 10.1093/genetics/92.4.1211.
3
Evidence for a Sex-Linked Haplo-Inviable Locus in the Cut-Singed Region of DROSOPHILA MELANOGASTER.证据表明，在果蝇的剪接区域存在一个与性别连锁的单倍体致死基因座。
Genetics. 1973 Aug;74(4):633-45. doi: 10.1093/genetics/74.4.633.
4
The distribution of randomly recovered X-ray-induced sex-linked genetic effects in Drosophila melanogaster.黑腹果蝇中随机恢复的X射线诱导的性连锁遗传效应的分布。
Genetics. 1981 Nov-Dec;99(3-4):461-80. doi: 10.1093/genetics/99.3-4.461.
5
Sex determination and dosage compensation in Drosophila melanogaster.黑腹果蝇的性别决定与剂量补偿
Annu Rev Genet. 1983;17:345-93. doi: 10.1146/annurev.ge.17.120183.002021.
6
The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene.染色体位置对果蝇黄嘌呤脱氢酶基因表达的影响。
Cell. 1983 Aug;34(1):47-57. doi: 10.1016/0092-8674(83)90135-6.
7
Analysis of P transposable element functions in Drosophila.果蝇中P转座因子功能的分析。
Cell. 1984 Aug;38(1):135-46. doi: 10.1016/0092-8674(84)90534-8.
8
Segmental aneuploidy and the genetic gross structure of the Drosophila genome.节段性非整倍体与果蝇基因组的遗传总体结构。
Genetics. 1972 May;71(1):157-84. doi: 10.1093/genetics/71.1.157.
9
Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states.有证据表明，无姐妹基因a和无姐妹基因b是果蝇X/A性别决定信号中几个离散的“分子元件”中的两个，它们在两种交替的稳定表达状态之间切换Sxl。
Genetics. 1988 Aug;119(4):829-62. doi: 10.1093/genetics/119.4.829.
10
Gene dosage compensation in Drosophila melanogaster.黑腹果蝇中的基因剂量补偿
Adv Genet. 1987;24:371-429. doi: 10.1016/s0065-2660(08)60013-9.

通过增加一个不连锁基因座的剂量来抑制黑腹果蝇的致死三体表型。

Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.

作者信息

Dorer D R, Cadden M A, Gordesky-Gold B, Harries G, Christensen A C

机构信息

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541.

出版信息

Genetics. 1993 May;134(1):243-9. doi: 10.1093/genetics/134.1.243.

DOI:10.1093/genetics/134.1.243
PMID:8514133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1205427/
Abstract

One of the most extreme examples of gene dosage sensitivity is the Triplo-lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.

摘要

基因剂量敏感性最极端的例子之一是黑腹果蝇第三条染色体上的三倍体致死位点（Tpl），该位点在单拷贝或三拷贝时均具有致死性。一个不连锁的位点Isis剂量增加可抑制Tpl的三倍体致死表型，但不能抑制单倍体致死表型。我们已将Isis定位到X染色体区域7E3 - 8A5，并表明这种抑制是一种基因剂量效应。在存在两份Tpl的情况下，改变Isis的剂量没有明显影响。通过研究Isis剂量与Tpl之间的相互作用，我们认为Isis并不直接抑制Tpl的表达，而是在Tpl的三倍体致死表型的下游起作用。