人溶酶体弹性蛋白酶对胰岛素氧化B链的作用。
Action of human lysosomal elastase on the oxidized B chain of insulin.
作者信息
Blow A M
出版信息
Biochem J. 1977 Jan 1;161(1):13-6. doi: 10.1042/bj1610013.
Abstract
The specificity of action of the lysosomal elastase of human neutrophil leucocytes on the oxidized B chain of insulin is similar to that of pig pancreatic elastase, but is more directed towards valine than alanine as the residue contributing the carboxyl group of the cleaved bond. The most susceptible bonds are Val-12-Glu-13 and Val-18-Cys(O3H)-19. Other bonds hydrolysed are Ala-14-Leu-15, Ser-9-His-10 and Cys, (O3H3)-7-Gly-8. Tables listing amino acid composition, N-terminal residue, and yields of isolated peptides have been deposited as Supplementary Publication SUP 50 075 (8 pages) at the British Library Lending Division, Boston Spa, Wetherby, West Yorkshire LS23 7BQ, U.K., from whom copies can be obtained on the terms indicated in Biochem. J. (1977) 161, 1.
摘要
人中性粒细胞溶酶体弹性蛋白酶对胰岛素氧化B链的作用特异性与猪胰弹性蛋白酶相似，但在作为裂解键羧基供体残基方面，对缬氨酸的作用比对丙氨酸更强。最敏感的键是Val-12-Glu-13和Val-18-Cys(O3H)-19。其他被水解的键是Ala-14-Leu-15、Ser-9-His-10和Cys,(O3H3)-7-Gly-8。列出氨基酸组成、N端残基和分离肽产量的表格已作为补充出版物SUP 50 075（8页）存放在英国西约克郡韦瑟比波士顿温泉市英国国家图书馆文献供应处，邮编LS23 7BQ，可按《生物化学杂志》（1977年）161, 1中所示条件从该处获取复印件。
相似文献
1
Action of human lysosomal elastase on the oxidized B chain of insulin.人溶酶体弹性蛋白酶对胰岛素氧化B链的作用。
Biochem J. 1977 Jan 1;161(1):13-6. doi: 10.1042/bj1610013.
2
Action of human cathepsin G on the oxidized B chain of insulin.人组织蛋白酶G对胰岛素氧化B链的作用。
Biochem J. 1977 Jan 1;161(1):17-9. doi: 10.1042/bj1610017.
3
The human erythrocyte anion-transport protein. Partial amino acid sequence, conformation and a possible molecular mechanism for anion exchange.人类红细胞阴离子转运蛋白。部分氨基酸序列、构象及阴离子交换的一种可能分子机制。
Biochem J. 1983 Sep 1;213(3):577-86. doi: 10.1042/bj2130577.
4
Amino acid sequence of cytochrome c from Tetrahymena pyriformis Phenoset A.梨形四膜虫Phenoset A细胞色素c的氨基酸序列。
Biochem J. 1976 Nov;159(2):193-9. doi: 10.1042/bj1590193.
5
The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides.粗糙脉孢菌NADP特异性谷氨酸脱氢酶的氨基酸序列。胰蛋白酶肽段
Biochem J. 1975 Sep;149(3):739-48. doi: 10.1042/bj1490739.
6
The amino acid sequence of the cytochrome c-554(547) from the chemolithotrophic bacterium Thiobacillus neapolitanus.来自化能自养细菌那不勒斯硫杆菌的细胞色素c-554(547)的氨基酸序列。
Biochem J. 1985 May 1;227(3):1009-13. doi: 10.1042/bj2271009.
7
Evidence for the amino acid sequence of porcine pancreatic elastase.猪胰弹性蛋白酶氨基酸序列的证据。
Biochem J. 1973 Apr;131(4):643-75. doi: 10.1042/bj1310643.
8
Locations of the six disulphide bonds in a variant surface glycoprotein (VSG 117) from Trypanosoma brucei.布氏锥虫变异表面糖蛋白（VSG 117）中六个二硫键的位置。
Biochem J. 1983 Feb 1;209(2):481-7. doi: 10.1042/bj2090481.
9
Prokaryote-eukaryote relationship and the amino acid sequence of plastocyanin from Anabaena variabilis.原核生物与真核生物的关系以及可变鱼腥藻质体蓝素的氨基酸序列
Biochem J. 1975 Sep;149(3):675-83. doi: 10.1042/bj1490675.
10
Chymotrypsins from the deer (Cervidae) family. Isolation, partial characterization and primary-structure studies of chymotrypsins A and B from both moose (Alces alces) and elk (Cervus elaphus) pancreas.鹿科动物的胰凝乳蛋白酶。驼鹿（Alces alces）和马鹿（Cervus elaphus）胰腺中胰凝乳蛋白酶A和B的分离、部分特性鉴定及一级结构研究。
Biochem J. 1976 Jun 1;155(3):549-66. doi: 10.1042/bj1550549.
引用本文的文献
1
Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity.人α1-抗胰蛋白酶P2残基在确定靶蛋白酶特异性中的作用。
PLoS One. 2017 Sep 18;12(9):e0185074. doi: 10.1371/journal.pone.0185074. eCollection 2017.
2
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.弹性蛋白酶特异性抑制剂弹性抑素在囊性纤维化患者的痰液中被其同源酶中性粒细胞弹性蛋白酶裂解。
J Biol Chem. 2008 Nov 21;283(47):32377-85. doi: 10.1074/jbc.M803707200. Epub 2008 Sep 17.
3
Structural and functional characterization of elastases from horse neutrophils.马中性粒细胞弹性蛋白酶的结构与功能特性
Biochem J. 1994 Jun 1;300 ( Pt 2)(Pt 2):401-6. doi: 10.1042/bj3000401.
4
The specificity of macrophage elastase on the insulin B-chain.巨噬细胞弹性蛋白酶对胰岛素B链的特异性。
Biochem J. 1981 May 1;195(2):369-72. doi: 10.1042/bj1950369.
5
Primary structure of human neutrophil elastase.人中性粒细胞弹性蛋白酶的一级结构。
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2228-32. doi: 10.1073/pnas.84.8.2228.
6
Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency.一种用于检测体内人中性粒细胞弹性蛋白酶活性的检测方法的开发。α1-蛋白酶抑制剂缺乏症患者弹性蛋白酶活性增加。
J Clin Invest. 1986 Jul;78(1):155-62. doi: 10.1172/JCI112545.
7
Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.蛋白酶3。一种独特的人类多形核白细胞蛋白酶，可在仓鼠中引发肺气肿。
J Clin Invest. 1988 Dec;82(6):1963-73. doi: 10.1172/JCI113816.
8
Dissociation of the chemotactic and mitogenic activities of platelet-derived growth factor by human neutrophil elastase.人中性粒细胞弹性蛋白酶对血小板衍生生长因子趋化活性和促有丝分裂活性的解离作用
J Cell Biol. 1985 Feb;100(2):351-6. doi: 10.1083/jcb.100.2.351.
9
Kinetics of the interaction of chymotrypsin with eglin c.胰凝乳蛋白酶与抑肽酶C相互作用的动力学
Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):27-32. doi: 10.1042/bj2800027.
10
Action of human cathepsin G on the oxidized B chain of insulin.人组织蛋白酶G对胰岛素氧化B链的作用。
Biochem J. 1977 Jan 1;161(1):17-9. doi: 10.1042/bj1610017.
本文引用的文献
1
[Amino acid determination on paper chromatograms].[纸色谱法测定氨基酸]
Hoppe Seylers Z Physiol Chem. 1957;309(4-6):219-20.
2
The specificity of purified porcine pancreatic elastase.纯化猪胰弹性蛋白酶的特异性
Biochem J. 1969 Aug;114(1):11-7. doi: 10.1042/bj1140011.
3
Inhibition of human leukocyte elastase by peptide chloromethyl ketones.
FEBS Lett. 1975 Feb 15;50(3):359-61. doi: 10.1016/0014-5793(75)80527-8.
4
Human lysosomal elastase. Catalytic and immunological properties.人溶酶体弹性蛋白酶。催化和免疫学特性。
Biochem J. 1976 May 1;155(2):265-71. doi: 10.1042/bj1550265.
5
Action of human cathepsin G on the oxidized B chain of insulin.人组织蛋白酶G对胰岛素氧化B链的作用。
Biochem J. 1977 Jan 1;161(1):17-9. doi: 10.1042/bj1610017.
6
Human cathepsin G. Catalytic and immunological properties.人组织蛋白酶G。催化和免疫学特性。
Biochem J. 1976 May 1;155(2):273-8. doi: 10.1042/bj1550273.
7
Neutral proteinases of human spleen. Purification and criteria for homogeneity of elastase and cathepsin G.人脾中的中性蛋白酶。弹性蛋白酶和组织蛋白酶G的纯化及均一性标准。
Biochem J. 1976 May 1;155(2):255-63. doi: 10.1042/bj1550255.
Zotero 插件