黄曲霉醌，由Humicola菌属产生的新型抗球虫剂。生产、分离以及理化和生物学特性。
Xanthoquinodins, new anticoccidial agents produced by Humicola sp. Production, isolation and physico-chemical and biological properties.
作者信息
Tabata N, Suzumura Y, Tomoda H, Masuma R, Haneda K, Kishi M, Iwai Y, Omura S
机构信息
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1993 May;46(5):749-55. doi: 10.7164/antibiotics.46.749.
Humicola sp. FO-888, a soil isolate, was found to produce a series of new anticoccidial compounds. Five active compounds, designated xanthoquinodins A1, A2, A3, B1 and B2 were isolated from the fermentation broth of the producing strain by solvent extraction and HPLC. Xanthoquinodins inhibited the growth of Eimeria tenella in an in vitro assay system using BHK-21 cells as a host. No schizont in the cells was observed at concentrations of 0.02-0.2 micrograms/ml for xanthoquinodins A1, A3, B1 and B2 and at 0.02 micrograms/ml for xanthoquinodin A2.
土生栖热放线菌FO-888是一种从土壤中分离出的菌株，被发现能产生一系列新的抗球虫化合物。通过溶剂萃取和高效液相色谱法，从该产生菌的发酵液中分离出了五种活性化合物，分别命名为黄醌素A1、A2、A3、B1和B2。在以BHK-21细胞为宿主的体外检测系统中，黄醌素能抑制柔嫩艾美耳球虫的生长。对于黄醌素A1、A3、B1和B2，在浓度为0.02 - 0.2微克/毫升时，细胞中未观察到裂殖体；对于黄醌素A2，在浓度为0.02微克/毫升时，细胞中未观察到裂殖体。
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