黄曲霉喹诺酮B3，一种由腐质霉属FO-888菌株产生的新型抗球虫剂。
Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp. FO-888.
作者信息
Tabata N, Tomoda H, Iwai Y, Omura S
机构信息
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1996 Mar;49(3):267-71. doi: 10.7164/antibiotics.49.267.
Xanthoquinodin B3, a new component of anticoccidial xanthoquinodins, which was detected in the culture broth of Humicola sp. FO-888, was isolated by heat treatment of the xanthoquinodins complex. Structural elucidation indicated that xanthoquinodin B3 has the same heterodimer of xanthone- and anthraquinone-derived monomers as other xanthoquinodins. Schizont formation of monensin-resistant Eimeria tenella in BHK-21 cells was inhibited by xanthoquinodin B3 at concentrations greater than 0.035 microM.
黄曲霉喹诺酮B3是抗球虫黄曲霉喹诺酮类的一种新成分，在Humicola sp. FO - 888的培养液中被检测到，通过对黄曲霉喹诺酮复合物进行热处理而分离得到。结构解析表明，黄曲霉喹诺酮B3与其他黄曲霉喹诺酮类具有相同的由呫吨酮和蒽醌衍生的单体异二聚体。在BHK - 21细胞中，浓度大于0.035微摩尔时，黄曲霉喹诺酮B3可抑制对莫能菌素耐药的柔嫩艾美耳球虫的裂殖体形成。
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