Thornsberry C, Marler J K, Watts J L, Yancey R J
Institutes for Microbiology Research, Franklin, Tennessee 37064.
Antimicrob Agents Chemother. 1993 May;37(5):1122-6. doi: 10.1128/AAC.37.5.1122.
Pirlimycin is an analog of clindamycin that will be recommended for therapy of bovine mastitis. It has good activity against staphylococci and streptococci, the major pathogens for bovine mastitis. Five hundred and thirty bacterial isolates recovered from cows with mastitis were studied to confirm the spectrum of activity and to develop recommendations for susceptibility testing. Pirlimycin is not active against isolates of Enterobacteriaceae, it varies in its activity against enterococci, and it is active against veterinary isolates of streptococci (MIC for 50% of strains tested, < or = 0.03 to 0.06 microgram/ml) and staphylococci (MIC for 50% of strains tested, 0.25 to 1.0 microgram/ml). On the basis of levels of drug attained in the milk with recommended dosing schedules, we chose MIC breakpoints of < or = 2 micrograms/ml for susceptibility and > or = 4 micrograms/ml for resistance. We also recommended a disk diffusion test using a disk containing 2 micrograms/ml and breakpoints of < or = 12 mm for resistance and > or = 13 mm for susceptibility.
吡利霉素是克林霉素的类似物，将被推荐用于治疗牛乳腺炎。它对葡萄球菌和链球菌有良好活性，而这两种菌是牛乳腺炎的主要病原体。对从患乳腺炎奶牛身上分离出的530株细菌进行了研究，以确定其活性谱并制定药敏试验建议。吡利霉素对肠杆菌科细菌分离株无活性，对肠球菌的活性有所不同，对兽医分离的链球菌（50%受试菌株的MIC，≤0.03至0.06微克/毫升）和葡萄球菌（50%受试菌株的MIC，0.25至1.0微克/毫升）有活性。根据推荐给药方案在牛奶中达到的药物水平，我们选择≤2微克/毫升作为敏感的MIC断点，≥4微克/毫升作为耐药的MIC断点。我们还推荐使用含2微克/毫升的纸片进行纸片扩散试验，耐药的断点为≤12毫米，敏感的断点为≥13毫米。
