Toraldo R, D'Avanzo M, Tolone C, Canino G, Iafusco F, Notarangelo L D, Ugazio A, Cirillo C
Dipartimento di Pediatrica, II Università di Napoli, Italy.
Pediatr Hematol Oncol. 1995 Sep-Oct;12(5):489-93. doi: 10.3109/08880019509009480.
We report an 18-year-old boy with common variable immunodeficiency who presented with splenomegaly as well as left axillary and lateral cervical lymphadenopathy. Main laboratory investigations showed severe thrombocytopenia. Epstein-Barr virus (EBV) DNA was detected in the patient's throat-washing specimens and lymph node biopsy. Lymphocytes from the lymph node biopsy were also positive for EBV nuclear antigen. Serology for EBV and cytomegalovirus was negative. A therapeutic attempt with acyclovir did not influence the course of infection. Six months' treatment with human lymphoblastoid interferon-alpha (IFN alfa) brought about the normalization of clinical and hematologic conditions. Detection on throat-washing specimens carried out 1 year after therapy was negative. Our preliminary experience suggests that human lymphoblastoid IFN-alpha is a valid alternative in therapy of immunodeficient EB virus-infected patients.
我们报告一名18岁患有常见可变免疫缺陷的男孩，他出现脾肿大以及左腋窝和颈部外侧淋巴结病。主要实验室检查显示严重血小板减少。在患者的咽拭子标本和淋巴结活检中检测到爱泼斯坦-巴尔病毒（EBV）DNA。淋巴结活检的淋巴细胞也对EBV核抗原呈阳性。EBV和巨细胞病毒的血清学检查为阴性。阿昔洛韦的治疗尝试对感染病程没有影响。用人淋巴母细胞干扰素-α（IFNα）治疗六个月使临床和血液学状况恢复正常。治疗1年后对咽拭子标本的检测为阴性。我们的初步经验表明，人淋巴母细胞IFN-α是免疫缺陷EB病毒感染患者治疗的有效替代方法。
