Heyneman C A
Idaho Drug Information Center, College of Pharmacy, Idaho State University, Pocatello, ID 83209, USA.
Ann Pharmacother. 1995 Jul-Aug;29(7-8):780-2. doi: 10.1177/106002809502907-822.
The empirical evidence supporting the use of topical NSAIDs in acute soft tissue injuries is weak. However, patient ratings of improvement consistently favor NSAID treatment over placebo. Although it is very difficult to differentiate the placebo effect from the natural course of improvement in these patients, the overall impression given by these studies is that of superior efficacy of topical NSAIDs over placebo. The study by Akermark and Forsskahl suggests that indomethacin applied topically is as effective as therapeutic doses of oral indomethacin. Further studies need to be conducted to generalize this conclusion to other NSAIDs. Studies comparing the relative efficacy of topical NSAIDs with counterirritants available over-the-counter (e.g., menthol, camphor, methylsalicylate) also would be useful.
支持在急性软组织损伤中使用外用非甾体抗炎药（NSAIDs）的经验证据不足。然而，患者对病情改善的评分始终显示，NSAIDs治疗优于安慰剂。尽管很难将安慰剂效应与这些患者病情改善的自然过程区分开来，但这些研究给出的总体印象是，外用NSAIDs的疗效优于安慰剂。阿克马克（Akermark）和福斯卡赫尔（Forsskahl）的研究表明，局部应用吲哚美辛与治疗剂量的口服吲哚美辛效果相当。需要进行进一步研究，以便将这一结论推广至其他NSAIDs。比较外用NSAIDs与非处方抗刺激剂（如薄荷醇、樟脑、水杨酸甲酯）相对疗效的研究也会很有帮助。
