Taly A B, Arunodaya G R, Rao S
Department of Neurology and Biostatistics, National Institute of Mental Health and Neuro Sciences, (NIMHANS), Bangalore, India.
Clin Auton Res. 1995 Sep;5(4):215-9. doi: 10.1007/BF01824010.
Dysautonomia is a common feature of Guillain-Barré (GB) syndrome and is sometimes the cause of significant morbidity and death. Changes in sympathetic skin response (SSR) may be one of the accompaniments of dysautonomia. An attempt was made to correlate SSR changes with clinical and electrophysiologic features in a group of 24 patients with GB syndrome fulfilling NINDS (National Institute of Neurological Disorders and Stroke) criteria. A total of nine patients had absent SSR. Thirteen patients had clinical dysautonomia, of whom five had absent SSR. Five patients had features of predominant axonal damage and preserved SSR. A trend towards correlation of SSR abnormalities with common peroneal nerve conduction parameters (velocity and compound muscle action potential amplitude) was noted. We conclude that SSR abnormalities are common in GB syndrome and may be complementary to bed-side tests for autonomic dysfunction.
自主神经功能障碍是吉兰-巴雷综合征（GB）的常见特征，有时是导致严重发病和死亡的原因。交感皮肤反应（SSR）的变化可能是自主神经功能障碍的伴随症状之一。我们试图将一组符合美国国立神经疾病和中风研究所（NINDS）标准的24例GB综合征患者的SSR变化与临床和电生理特征进行关联。共有9例患者SSR消失。13例患者有临床自主神经功能障碍，其中5例SSR消失。5例患者有以轴索性损害为主且SSR保留的特征。我们注意到SSR异常与腓总神经传导参数（速度和复合肌肉动作电位幅度）之间存在相关趋势。我们得出结论，SSR异常在GB综合征中很常见，可能是床边自主神经功能障碍检测的补充手段。
