Bruce C, Tall A R
Department of Medicine, Columbia University, New York, USA.
Curr Opin Lipidol. 1995 Oct;6(5):306-11. doi: 10.1097/00041433-199510000-00010.
Plasma cholesteryl ester transfer protein plays a central role in lipoprotein metabolism by exchanging cholesteryl esters with triglycerides. Human genetic deficiency is associated with increased HDL-cholesterol levels, whereas cholesteryl ester transfer protein overexpression in transgenic mice results in decreased HDL-cholesterol. Thus, it has been proposed that cholesteryl ester transfer protein deficiency is an antiatherogenic state. However, recent observations in human cholesteryl ester transfer protein deficiency and cholesteryl ester transfer protein transgenic mice also suggest antiatherogenic effects of the expression of this protein, probably reflecting its role in reverse cholesterol transport.
血浆胆固醇酯转运蛋白通过与甘油三酯交换胆固醇酯在脂蛋白代谢中起核心作用。人类基因缺陷与高密度脂蛋白胆固醇水平升高相关，而在转基因小鼠中胆固醇酯转运蛋白过表达则导致高密度脂蛋白胆固醇水平降低。因此，有人提出胆固醇酯转运蛋白缺乏是一种抗动脉粥样硬化状态。然而，最近对人类胆固醇酯转运蛋白缺乏症和胆固醇酯转运蛋白转基因小鼠的观察也表明该蛋白表达具有抗动脉粥样硬化作用，这可能反映了其在胆固醇逆向转运中的作用。
