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加瓦色林和沙尔他瓦林,由多粘芽孢杆菌产生的新型肽类抗生素。

Gavaserin and saltavalin, new peptide antibiotics produced by Bacillus polymyxa.

作者信息

Pichard B, Larue J P, Thouvenot D

机构信息

Laboratoire de Microbiologie et Biochimie ISAMOR, Technopôle Brest-Iroise, Plouzane, France.

出版信息

FEMS Microbiol Lett. 1995 Nov 15;133(3):215-8. doi: 10.1111/j.1574-6968.1995.tb07887.x.

DOI:10.1111/j.1574-6968.1995.tb07887.x
PMID:8522137
Abstract

A strain of Bacillus polymyxa (BPl), isolated from cauliflower seeds, inhibited the growth of microbial phytopathogens. Growth of this strain in liquid medium containing lactose, ammonium sulfate, biotin, and amino acids, resulted in optimal inhibition in vitro. Two new antibacterial substances were isolated and purified from culture broth. Their molecular masses were, respectively, 911 and 903 daltons. The first compound was named gavaserin because it contained glutamic acid, alanine, valine, serine and 2,4-diaminobutyric acid, and octanoic acid. No fatty acid was detected in the second compound, which was named saltavalin because it contained serine, alanine, leucine, threonine, valine, and 2,4-diaminobutyric acid.

摘要

从花椰菜种子中分离出的一种多粘芽孢杆菌(BPl)菌株能够抑制微生物植物病原体的生长。该菌株在含有乳糖、硫酸铵、生物素和氨基酸的液体培养基中生长,可在体外产生最佳抑制效果。从培养液中分离并纯化出两种新的抗菌物质。它们的分子量分别为911和903道尔顿。第一种化合物被命名为gavaserin,因为它含有谷氨酸、丙氨酸、缬氨酸、丝氨酸、2,4 - 二氨基丁酸和辛酸。第二种化合物中未检测到脂肪酸,它被命名为saltavalin,因为它含有丝氨酸、丙氨酸、亮氨酸、苏氨酸、缬氨酸和2,4 - 二氨基丁酸。

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Gavaserin and saltavalin, new peptide antibiotics produced by Bacillus polymyxa.加瓦色林和沙尔他瓦林,由多粘芽孢杆菌产生的新型肽类抗生素。
FEMS Microbiol Lett. 1995 Nov 15;133(3):215-8. doi: 10.1111/j.1574-6968.1995.tb07887.x.
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