两种博来霉素放射免疫测定法与一种微生物测定法的比较。

Comparison of two radioimmunoassays and a microbiologic assay for bleomycin.

作者信息

Elson M K, Oken M M, Shafer R B, Broughton A, Strong J, Braun C T, Crooke S T

出版信息

Med Pediatr Oncol. 1978;5(1):213-8. doi: 10.1002/mpo.2950050129.

Abstract

Recently two radioimmunoassays have been independently developed for determination of bleomycin levels. In this study these assays are compared with each other and with a standard microbiologic assay for bleomycin. Bleomycin levels were determined in serum and urine samples obtained at varying intervals following intramuscular bleomycin injection. There were systematic differences between the assays. One radioimmunoassay indicated bleomycin levels lower than the levels indicated by the microbiologic assay with serum samples. With urine samples, both radioimmunoassays indicated bleomycin levels greater than the microbiologic assay.

摘要

最近，两种用于测定博来霉素水平的放射免疫测定法已被独立开发出来。在本研究中，对这些测定法相互之间以及与一种博来霉素标准微生物测定法进行了比较。在肌肉注射博来霉素后，于不同时间间隔采集血清和尿液样本，并测定其中的博来霉素水平。这些测定法之间存在系统性差异。一种放射免疫测定法显示血清样本中的博来霉素水平低于微生物测定法所显示的水平。对于尿液样本，两种放射免疫测定法显示的博来霉素水平均高于微生物测定法。