Ofori-Anyinam O, Vrijsen R, Kronenberger P, Boeyé A
Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
Vaccine. 1995 Aug;13(11):983-6. doi: 10.1016/0264-410x(95)00036-z.
Polioviruses type 1 (Mahoney) and type 3 (Sabin) were treated with the antiviral pyridazinamine R78206 by first binding the compound to the virus and then removing unbound compound by dialysis. As a result of this treatment, both poliovirus strains were protected against thermal inactivation at 46 degrees C. The R78206 treatment did not cause inactivation except with the Sabin 3 strain at high R78206 concentrations.
