Stapleton J M, Morgan M J, Phillips R L, Wong D F, Yung B C, Shaya E K, Dannals R F, Liu X, Grayson R L, London E D
Division of Intramural Research, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Neuropsychopharmacology. 1995 Aug;13(1):21-31. doi: 10.1016/0893-133X(94)00132-J.
Regional cerebral glucose metabolism in subjects with histories of polysubstance abuse was compared to that in control subjects who were drawn from the same community. The substance abuse group showed lower absolute metabolic rates for glucose in lateral occipital gyrus and higher normalized metabolic rates in temporal and frontal areas, including orbitofrontal cortex. It is suggested that some patterns of brain function associated with polysubstance abuse may represent consequences of drug exposure, or they could reflect pre-existing differences that may be relevant to the etiology and maintenance of polysubstance abuse.
将有多种物质滥用史的受试者的局部脑葡萄糖代谢与来自同一社区的对照受试者进行比较。物质滥用组在枕外侧回显示出较低的葡萄糖绝对代谢率，而在颞叶和额叶区域，包括眶额皮质，显示出较高的标准化代谢率。有人提出，与多种物质滥用相关的一些脑功能模式可能代表药物暴露的后果，或者它们可能反映了与多种物质滥用的病因和维持相关的预先存在的差异。
