西咪替丁对人体食管下括约肌的作用。
Effect of cimetidine on the human lower oesophageal sphincter.
作者信息
Osborne D H, Lennon J, Henderson M, Lidgard G, Creel R, Carter D C
出版信息
Gut. 1977 Feb;18(2):99-104. doi: 10.1136/gut.18.2.99.
Abstract
Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrations during cimetidine infusion were measured by radioimmunoassay and showed no significant variation. In a further series of experiments, the response of the lower oesophageal sphincter to intravenous bolus injection of pentagastrin was measured before and during cimetidine infusion. Cimetidine infusion had no significant effect on the sphincter response to pentagastrin.
摘要
在健康志愿者静脉输注组胺H2受体拮抗剂西咪替丁期间，采用快速牵拉技术测量其食管下括约肌压力。未观察到对括约肌压力有一致的、可能具有临床重要性的影响。采用放射免疫分析法测量西咪替丁输注期间的血清胃泌素浓度，结果显示无显著变化。在另一系列实验中，测量了西咪替丁输注前和输注期间食管下括约肌对静脉推注五肽胃泌素的反应。西咪替丁输注对括约肌对五肽胃泌素的反应无显著影响。
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本文引用的文献
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J Clin Invest. 1971 Feb;50(2):449-54. doi: 10.1172/JCI106512.
2
Hormonal control of gastroesophageal-sphincter strength.胃食管括约肌力量的激素调控
N Engl J Med. 1970 Apr 16;282(16):886-9. doi: 10.1056/NEJM197004162821602.
3
Action of gastrin on the lower oesophageal sphincter in man.胃泌素对人食管下括约肌的作用。
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Intraluminal esophageal manometry: an analysis of variables affecting recording fidelity of peristaltic pressures.腔内食管测压：影响蠕动压力记录保真度的变量分析
Gastroenterology. 1974 Aug;67(2):221-30.
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Stimulation of the incompetent lower esophageal sphincter. A possible advance in therapy of heartburn.对功能不全的食管下括约肌的刺激。治疗胃灼热的一种可能进展。
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