College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, Sichuan, People's Republic of China.
J Mater Sci Mater Med. 2010 May;21(5):1463-71. doi: 10.1007/s10856-010-4025-5. Epub 2010 Feb 17.
The aim of this research was to investigate the effect of the chemical composition on the mechanical properties, bioactivity, and cytocompatibility in vitro of bioceramics in the MgO-CaO-SiO(2) system. Three single-phase ceramics (merwinite, akermanite and monticellite ceramics) with different MgO contents were fabricated. The mechanical properties were tested by an electronic universal machine, while the bioactivity in vitro of the ceramics was detected by investigating the bone-like apatite-formation ability in simulated body fluid (SBF), and the cytocompatibility was evaluated through osteoblast proliferation and adhesion assay. The results showed that their mechanical properties were improved from merwinite to akermanite and monticellite ceramics with the increase of MgO contents, whereas the apatite-formation ability in SBF and cell proliferation decreased. Furthermore, osteoblasts could adhere, spread and proliferate on these ceramic wafers. Finally, the elongated appearance and minor filopodia of cells on merwinite ceramic were more obvious than the other two ceramics.
本研究旨在探讨 MgO-CaO-SiO2 系统生物陶瓷的化学成分对其力学性能、生物活性和体外细胞相容性的影响。制备了三种具有不同 MgO 含量的单相陶瓷（镁蔷薇辉石、铁辉石和镁橄榄石陶瓷）。通过电子万能试验机测试了它们的力学性能，通过在模拟体液（SBF）中检测骨样磷灰石形成能力来检测其体外生物活性，并通过成骨细胞增殖和黏附试验评估其细胞相容性。结果表明，随着 MgO 含量的增加，它们的力学性能从镁蔷薇辉石陶瓷提高到铁辉石和镁橄榄石陶瓷，而 SBF 中的磷灰石形成能力和细胞增殖能力降低。此外，成骨细胞可以在这些陶瓷片上黏附、铺展和增殖。最后，细胞在镁蔷薇辉石陶瓷上的长形外观和少量丝状伪足比其他两种陶瓷更明显。
