Nishimura M, Takahashi H, Nanbu A, Habuchi Y, Fujita N, Nakanishi T, Yoshimura M
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Japan.
Hypertens Res. 1995 Jun;18 Suppl 1:S191-2. doi: 10.1291/hypres.18.supplementi_s191.
We investigated whether urinary excretion of free dopamine is related with the humoral factors which affect Na+, K+ ATPase activity in the kidneys. Subjects were 51 adults admitted in a hospital without renal insufficiency: they were divided into normotensive (n = 36, 60 +/- 3 years old, 122 +/- 3/73 +/- 2 mmHg) and hypertensive groups (n = 15, 65 +/- 5 years old, 157 +/- 6/91 +/- 2 mmHg). Urinary excretion of free dopamine was significantly and positively correlated with urinary excretion of C-peptide immunoreactivity of insulin (CPR) (r = 0.451, p = 0.014) in normotensive subjects, but not in hypertensive subjects (r = 0.155, p = 0.668). Urinary excretion of endogenous digoxinlike substances (EDLS) was also significantly and positively correlated with urinary CPR (r = 0.500, p = 0.006) in normotensive subjects, but not in hypertensive subjects (r = 0.275, p = 0.363). In normotensive subjects, urinary excretion of free dopamine and EDLS may be regulated at least in part by insulin secreted endogenously. In hypertensive subjects, however, this regulatory mechanism of the diuretic factors, such as insulin, EDLS and dopamine, is thought to be deranged, which might result in decompensation of a diuretic and antidiuretic balance leading to blood pressure elevation.
我们研究了游离多巴胺的尿排泄是否与影响肾脏中钠钾ATP酶活性的体液因子相关。研究对象为51名入住医院且无肾功能不全的成年人：他们被分为血压正常组（n = 36，年龄60±3岁，血压122±3/73±2 mmHg）和高血压组（n = 15，年龄65±5岁，血压157±6/91±2 mmHg）。在血压正常的受试者中，游离多巴胺的尿排泄与胰岛素的C肽免疫反应性（CPR）的尿排泄显著正相关（r = 0.451，p = 0.014），但在高血压受试者中无此相关性（r = 0.155，p = 0.668）。内源性洋地黄样物质（EDLS）的尿排泄在血压正常的受试者中也与尿CPR显著正相关（r = 0.500，p = 0.006），但在高血压受试者中无此相关性（r = 0.275，p = 0.363）。在血压正常的受试者中，游离多巴胺和EDLS的尿排泄可能至少部分受内源性分泌的胰岛素调节。然而，在高血压受试者中，胰岛素、EDLS和多巴胺等利尿因子的这种调节机制被认为是紊乱的，这可能导致利尿和抗利尿平衡失调，从而导致血压升高。
