Spieker S, Schulz J B, Petersen D, Fetter M, Klockgether T, Dichgans J
Department of Neurology, University of Tübingen, Germany.
J Neurol. 1995 Aug;242(8):517-21. doi: 10.1007/BF00867423.
Eye movements were studied in 13 patients with Friedreich's ataxia and correlated with MRI findings to investigate whether oculomotor abnormalities can be traced to cerebellar disturbances in this disease. One of the most prominent eye signs was fixation instability (square-wave jerks, SWJ.). Besides SWJ the patients showed various combinations of cerebellar, vestibular and brain-stem oculomotor signs. Our patients did not comprise a homogeneous group with regard to their oculomotor findings. There was no correlation between the severity of any of the so-called cerebellar oculomotor disturbances and the number of SWJ. We tried to correlate the extent of oculomotor disturbances with floccular atrophy and atrophy of the dorsal vermis on MRI in seven of the patients. None of the oculomotor features (including SWJ) correlated with flocculus or dorsal vermis size. Furthermore, floccular and vermal measurements on MRI were normal. Accordingly, we think it unlikely that the oculomotor disturbances, including SWJ, are attributable to cerebellar pathology per se.
对13例弗里德赖希共济失调患者的眼球运动进行了研究，并与MRI结果相关联，以调查在这种疾病中眼球运动异常是否可追溯到小脑功能障碍。最突出的眼部体征之一是注视不稳定（方波急跳，SWJ）。除SWJ外，患者还表现出小脑、前庭和脑干眼球运动体征的各种组合。就其眼球运动结果而言，我们的患者并非一个同质群体。任何所谓的小脑眼球运动障碍的严重程度与SWJ的数量之间均无相关性。我们试图将7例患者眼球运动障碍的程度与MRI上的绒球萎缩和小脑蚓部背侧萎缩相关联。没有任何眼球运动特征（包括SWJ）与绒球或小脑蚓部大小相关。此外，MRI上的绒球和蚓部测量结果正常。因此，我们认为包括SWJ在内的眼球运动障碍不太可能归因于小脑本身的病变。
