通过兔出血症病毒与单克隆抗体的反应性研究其抗原性。
Antigenicity of the rabbit hemorrhagic disease virus studied by its reactivity with monoclonal antibodies.
作者信息
Capucci L, Frigoli G, Rønshold L, Lavazza A, Brocchi E, Rossi C
机构信息
Department of Virology, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia, Brescia, Italy.
出版信息
Virus Res. 1995 Aug;37(3):221-38. doi: 10.1016/0168-1702(95)00033-m.
A panel of anti-rabbit hemorrhagic disease virus (anti-RHDV) monoclonal antibodies was produced and characterized. The ability of the MAbs to recognize epitopes present on RHDV capsids, European brown hare syndrome virus capsids and RHDV subunits was determined. Preliminary results on the neutralizing capacity of the MAbs were obtained by in vivo protection experiments. The antigenic map of RHDV obtained by this study is consistent with the current models of the calicivirus structure.
制备并鉴定了一组抗兔出血性疾病病毒（抗RHDV）单克隆抗体。测定了这些单克隆抗体识别RHDV衣壳、欧洲棕兔综合征病毒衣壳和RHDV亚基上存在的表位的能力。通过体内保护实验获得了这些单克隆抗体中和能力的初步结果。本研究获得的RHDV抗原图谱与杯状病毒结构的当前模型一致。
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