来自第十四条染色体的一个8.2千碱基对的DNA片段携带RPD3和PAS8基因，以及硫胺素抑制的nmt1基因的酿酒酵母同源物和一个假定的芳基醇脱氢酶的第三条染色体重复基因。
An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol dehydrogenase.
作者信息
Van Dyck L, Pascual-Ahuir A, Purnelle B, Goffeau A
机构信息
Unité de Biochimie Physiologique, Université Catholique de Louvain, Belgium.
出版信息
Yeast. 1995 Aug;11(10):987-91. doi: 10.1002/yea.320111010.
A 8.2 kb DNA segment from the left arm of Saccharomyces cerevisiae chromosome XIV (GenBank/EMBL accession number: X83226) encompasses four open reading frames (ORFs) longer than 100 residues. The ORF N0295 is highly similar to the Aspergillus parasiticus and Schizosaccharomyces pombe nmt1 gene products, which are involved in thiamine biosynthesis and are strongly repressed by thiamine. N0300 is 76% identical to YCR107w, a hypothetical protein of yeast chromosome III, and 55% identical to a ligninolytic aryl-alcohol dehydrogenase from the white-rot fungus Phanerochaete chrysosporium. In addition, this fragment encodes Rpd3, a pleiotropic transcription factor (Vidal and Gaber, 1991), and part of Pas8, a protein essential for the biogenesis of peroxisomes (Voorn-Brouwer et al., 1993).
来自酿酒酵母第十四号染色体左臂的一段8.2 kb DNA片段（基因库/欧洲分子生物学实验室登录号：X83226）包含四个长度超过100个残基的开放阅读框（ORF）。ORF N0295与寄生曲霉和粟酒裂殖酵母的nmt1基因产物高度相似，这些产物参与硫胺素生物合成，并受到硫胺素的强烈抑制。N0300与酵母第三号染色体上的一个假定蛋白YCR107w有76%的同一性，与白腐真菌黄孢原毛平革菌的一种木质素分解芳基醇脱氢酶有55%的同一性。此外，该片段编码多效转录因子Rpd3（维达尔和加伯，1991年）以及过氧化物酶体生物发生所必需的蛋白质Pas8的一部分（沃恩-布劳威尔等人，1993年）。
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