Hoffmann J J, Cole J R
J Pharm Sci. 1977 Sep;66(9):1336-8. doi: 10.1002/jps.2600660935.
An ethanol extract of Adenium obesum exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx test system. Constituents in the active extract were identified as the cardenolides somalin, hongheloside A, 16-acetylstrospeside, and honghelin and the flavonol 3,3'-bis(O-methyl)quercetin. Their identities were proven by IR, UV, proton magnetic resonance, and mass spectrometry; elemental analyses; preparation of derivatives; and melting-point determinations. An inactive triterpene, dihydroifflaionic acid, and an inactive flavonol, 3-O-methylkaempferol, also were isolated and identified.
沙漠玫瑰的乙醇提取物对人鼻咽癌测试系统表现出细胞毒性活性。活性提取物中的成分被鉴定为强心苷类的索马里苷、红河苷A、16-乙酰毒毛旋花子苷、红河苷以及黄酮醇3,3'-双（O-甲基）槲皮素。通过红外光谱、紫外光谱、质子磁共振和质谱分析；元素分析；衍生物制备；以及熔点测定证实了它们的结构。还分离并鉴定出一种无活性的三萜类化合物二氢异黄酮酸和一种无活性的黄酮醇3-O-甲基山奈酚。
