Schaper W
W. G. Kerckhoff-Institut, Max-Planck-Institut für physiologische und klinische Forschung Abt. Experimentelle Kardiologie, Bad Nauheim.
Basic Res Cardiol. 1995 Jul-Aug;90(4):273-5. doi: 10.1007/BF00797897.
Brief coronary occlusions cause stunning and ischemic preconditioning, the molecular mechanisms of which are insufficiently known. A marked reprogramming of sarcolemmal functions (including those of the sarcoplasmic reticulum) seems to occur and may be the basis for many of the observed phenomena. A bewilderingly complex pattern of gene expression emerges from mRNA-studies with reperfused tissue which at present does not permit a focussed or coherent view of mechanisms.
短暂的冠状动脉闭塞会导致心肌顿抑和缺血预处理,但其分子机制尚不完全清楚。肌膜功能(包括肌浆网功能)似乎发生了显著的重编程,这可能是许多观察到的现象的基础。对再灌注组织进行的mRNA研究呈现出一种极其复杂的基因表达模式,目前还无法对其机制形成集中或连贯的认识。