Sasakawa T, Takizawa H, Bannai H, Narisawa R, Asakura H
3rd Department of Internal Medicine, Niigata University School of Medicine, Japan.
Digestion. 1995;56(6):516-22. doi: 10.1159/000201285.
This study was performed to clarify the relationship between activated (HLA-DR-expressing) CD4+ and CD8+ cells in the colonic lamina propria of ulcerative colitis and other immunological factors, i.e., epithelial DR expression, serum soluble CD25 levels, and colonic mucosal CD25+ cells. The frequency of epithelial DR expression was positively correlated with the numbers of CD4+ and CD8+ cells. The percentages activated CD4+/CD4+ cells were higher in mucosae with DR- epithelium than in mucosae with DR+ epithelium. The serum soluble CD25 levels were increased in ulcerative colitis, and there was an inverse correlation between these levels and the relative number of activated CD4+ cells in untreated active disease. These results suggest that interactions among mucosal CD4+ cells, colonic epithelium, and serum soluble CD25 might play an important role in the pathogenesis of ulcerative colitis.
本研究旨在阐明溃疡性结肠炎患者结肠固有层中活化的（表达HLA - DR的）CD4⁺和CD8⁺细胞与其他免疫因素之间的关系，即上皮细胞DR表达、血清可溶性CD25水平和结肠黏膜CD25⁺细胞。上皮细胞DR表达频率与CD4⁺和CD8⁺细胞数量呈正相关。与DR⁺上皮的黏膜相比，DR⁻上皮的黏膜中活化的CD4⁺/CD4⁺细胞百分比更高。溃疡性结肠炎患者血清可溶性CD25水平升高，且在未经治疗的活动性疾病中，这些水平与活化CD4⁺细胞的相对数量呈负相关。这些结果表明，黏膜CD4⁺细胞、结肠上皮和血清可溶性CD25之间的相互作用可能在溃疡性结肠炎的发病机制中起重要作用。
