Chuck S, Grant R M, Katongole-Mbidde E, Conant M, Ganem D
Howard Hughes Medical Institute, University of California, San Francisco 94143, USA.
J Infect Dis. 1996 Jan;173(1):248-51. doi: 10.1093/infdis/173.1.248.
While Kaposi's sarcoma (KS) is extremely common in homosexual men infected with human immunodeficiency virus (HIV), it is also found in several clinical settings in which HIV infection is absent. Recently, sequences from the genome of a novel member of the herpesvirus family have been identified within KS biopsies in the AIDS-associated form of the disease. The presence of these sequences was sought in 6 cases of HIV-negative KS, including 4 cases of endemic KS from Africa, and was found in 5 of the 6. These findings strengthen the association between infection with this virus and the development of KS and argue against the notion that this association is simply the result of opportunistic superinfection of profoundly immunodeficient hosts.
虽然卡波西肉瘤（KS）在感染人类免疫缺陷病毒（HIV）的同性恋男性中极为常见，但在一些未感染HIV的临床环境中也能发现。最近，在艾滋病相关形式的KS活检组织中，已鉴定出疱疹病毒家族一个新成员基因组的序列。在6例HIV阴性的KS病例中寻找这些序列的存在情况，其中包括4例来自非洲的地方性KS病例，结果在6例中的5例中发现了这些序列。这些发现强化了这种病毒感染与KS发生之间的关联，并反驳了这种关联仅仅是深度免疫缺陷宿主机会性重叠感染结果的观点。
