Arimoto T, Toratani A, Ito K, Iwasaki Y, Nakamura T, Nakagawa M
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Sep;33(9):917-23.
A marked transient increase in blood pressure can occur at the end of each apneic period in patients with sleep apnea syndrome (SAS) and SAS may be a risk factor for cerebrovascular disease. To estimate blood pressure variability during apnea arterial blood pressure was directly and continuously recorded, and the transient increase in blood pressure in each sleep stage was assessed. Polysomnography was done in 5 men with SAS: arterial blood pressure, oxygen saturation, and respiratory curves were recorded. The maximum arterial blood pressure during the apneic period was compared with that at the end of apnea. The transient increase in blood pressure was 32.2 +/- 5.8 mmHg (mean +/- S.E.) for systolic pressure and 18.2 +/- 2.1 mmHg for diastolic pressure. During REM sleep, the values were 38.8 +/- 6.6 mmHg for systolic pressure and 23.4 +/- 2.2 mmHg for diastolic pressure. The increase in arterial blood pressure was significantly higher during REM sleep than during N-REM sleep (p < 0.05). This wide variation in blood pressure suggests that SAS is a risk factor for cerebrovascular disease, and that SAS may promote essential hypertension.
睡眠呼吸暂停综合征（SAS）患者在每次呼吸暂停期结束时可出现明显的血压短暂升高，且SAS可能是脑血管疾病的一个危险因素。为评估呼吸暂停期间的血压变异性，直接连续记录动脉血压，并评估每个睡眠阶段的血压短暂升高情况。对5名患有SAS的男性进行了多导睡眠图检查：记录动脉血压、血氧饱和度和呼吸曲线。将呼吸暂停期的最高动脉血压与呼吸暂停结束时的血压进行比较。收缩压的血压短暂升高为32.2±5.8 mmHg（平均值±标准误），舒张压为18.2±2.1 mmHg。在快速眼动睡眠期间，收缩压值为38.8±6.6 mmHg，舒张压为23.4±2.2 mmHg。快速眼动睡眠期间动脉血压的升高显著高于非快速眼动睡眠期间（p<0.05）。这种血压的广泛变化表明，SAS是脑血管疾病的一个危险因素，且SAS可能会促进原发性高血压。
