环境中新隐球菌分离株的甾醇组成及对两性霉素B的敏感性会因在小鼠体内传代而发生改变。
Sterol compositions and susceptibilities to amphotericin B of environmental Cryptococcus neoformans isolates are changed by murine passage.
作者信息
Currie B, Sanati H, Ibrahim A S, Edwards J E, Casadevall A, Ghannoum M A
机构信息
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
Antimicrob Agents Chemother. 1995 Sep;39(9):1934-7. doi: 10.1128/AAC.39.9.1934.
Abstract
Previous studies have shown that sequential isolates from patients with persistent Cryptococcus neoformans meningoencephalitis can vary in sterol composition and susceptibility to antifungal drugs. To investigate the potential of host factors as mediators of this phenomenon, we compared fungal susceptibilities of environmental and clinical isolates from a limited geographic area. Clinical isolates were less susceptible to amphotericin B than environmental isolates. Five environmental isolates were passaged through BALB/c murine hosts; the passaged isolates had changes in sterol composition and reduced amphotericin B susceptibilities relative to those of the parent isolates. In contrast, murine passage of these isolates did not alter their susceptibilities to fluconazole. The results confirm that changes in sterol composition and antifungal susceptibility can occur in vivo as a result of host factors and suggest that human infection can result in selection of variants with reduced susceptibilities to amphotericin B.
摘要
先前的研究表明，患有持续性新型隐球菌性脑膜脑炎患者的序贯分离株在甾醇组成和对抗真菌药物的敏感性方面可能存在差异。为了研究宿主因素作为这一现象介导因素的可能性，我们比较了来自有限地理区域的环境分离株和临床分离株的真菌易感性。临床分离株对两性霉素B的敏感性低于环境分离株。将5株环境分离株通过BALB/c小鼠宿主传代；传代后的分离株相对于亲本分离株，甾醇组成发生了变化，对两性霉素B的敏感性降低。相比之下，这些分离株在小鼠体内传代并未改变它们对氟康唑的敏感性。结果证实，由于宿主因素，甾醇组成和抗真菌敏感性的变化可在体内发生，并表明人类感染可导致对两性霉素B敏感性降低的变异株的选择。
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