Pitt M A, Morphopoulos G, Wells S, Bisset D L
Department of Histopathology, Bolton General Hospital.
J Clin Pathol. 1995 Nov;48(11):1059-61. doi: 10.1136/jcp.48.11.1059.
Two cases of pseudoangiosarcomatous carcinoma of the genitourinary tract, arising in the vulva in one and the bladder in the other, are presented. In case 1, an 84 year old woman, the vulvectomy specimen contained an irregular ulcerated tumour, infiltrating the left labia and extending into the clitoris. In case 2, a 59 year old woman, the excised bladder showed diffuse thickening of its wall by infiltrating haemorrhagic tumour. Both tumours showed focal keratinisation. This, in association with the presence of atypical squamous epithelium, immunohistochemistry and ultrastructural analysis, led to a diagnosis of pseudosarcomatous carcinoma in both cases. Pseudoangiosarcomatous carcinoma should be considered in the differential diagnosis of malignant angiomatoid tumours, particularly those that arise at sites, like the genitourinary tract, where angiosarcoma is rare.
本文报告了两例泌尿生殖道假血管肉瘤样癌，一例发生于外阴，另一例发生于膀胱。病例1为一名84岁女性，外阴切除标本中有一个不规则溃疡型肿瘤，浸润左侧阴唇并延伸至阴蒂。病例2为一名59岁女性，切除的膀胱显示因浸润性出血性肿瘤而导致壁弥漫性增厚。两个肿瘤均显示局灶性角化。结合非典型鳞状上皮的存在、免疫组织化学和超微结构分析，两例均诊断为假肉瘤样癌。在鉴别诊断恶性血管瘤样肿瘤时，应考虑假血管肉瘤样癌，尤其是那些发生于血管肉瘤罕见部位（如泌尿生殖道）的肿瘤。
