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人尿液和乳汁中的免疫球蛋白E

IGE in human urine and milk.

作者信息

Turner M W, McClelland D B, Medlen A R, Stokes C R

出版信息

Scand J Immunol. 1977;6(4):343-8. doi: 10.1111/j.1365-3083.1977.tb00403.x.

DOI:10.1111/j.1365-3083.1977.tb00403.x
PMID:854709
Abstract

IgE was found in urine from healthy adult volunteers at very low levels (approximately 0.003-0.010 IU/ml), corresponding to a 24-h excrection rate of 3-16 IU. IgE was not detected in 36 out of 47 samples of milk and colostrum. In samples from six women the protein was present at low concentration 1-2 days postpartum but was not detected in later samples (usually day 5 or 6). Mammary secretions from four allergic donors were studied, and IgE was detected at low concentrations in samples from the two most severely affected individuals. The levels of IgE observed in both urine and milk suggest that there is no significant synthesis of the protein in either the urinary tract or in mammary tissue.

摘要

在健康成年志愿者的尿液中发现了极低水平的IgE(约0.003 - 0.010 IU/ml),相当于24小时排泄率为3 - 16 IU。47份牛奶和初乳样本中有36份未检测到IgE。在6名女性的样本中,产后1 - 2天蛋白质浓度较低,但在后期样本(通常是第5天或第6天)中未检测到。对4名过敏供体的乳腺分泌物进行了研究,在两名受影响最严重个体的样本中检测到低浓度的IgE。在尿液和牛奶中观察到的IgE水平表明,尿路或乳腺组织中该蛋白质的合成均不显著。

相似文献

1
IGE in human urine and milk.人尿液和乳汁中的免疫球蛋白E
Scand J Immunol. 1977;6(4):343-8. doi: 10.1111/j.1365-3083.1977.tb00403.x.
2
IgE and IgD in human colostrum and plasma.人初乳和血浆中的免疫球蛋白E和免疫球蛋白D
Pediatr Res. 1982 Aug;16(8):604-7. doi: 10.1203/00006450-198208000-00004.
3
Total IgE levels in human colostrum.
Pediatr Allergy Immunol. 1996 Feb;7(1):44-7. doi: 10.1111/j.1399-3038.1996.tb00104.x.
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IgG4 in human colostrum and human milk: continued local production or selective transport from serum.人初乳和母乳中的IgG4:是持续的局部产生还是从血清中选择性转运。
Acta Paediatr Scand. 1988 Jan;77(1):24-9. doi: 10.1111/j.1651-2227.1988.tb10592.x.
5
Effect of breast milk of healthy and allergic mothers on in vitro stimulation of cord blood lymphocytes.健康母亲和过敏母亲的母乳对脐血淋巴细胞体外刺激的影响。
Pediatr Allergy Immunol. 2007 Sep;18(6):486-94. doi: 10.1111/j.1399-3038.2007.00563.x. Epub 2007 Jul 25.
6
Comparison of procedures for measurement of IgE protein in serum and secretions.
J Allergy Clin Immunol. 1977 May;59(5):377-82. doi: 10.1016/0091-6749(77)90022-7.
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A reappraisal of IgE levels in various human secretions by particle counting immunoassay combined with pepsin digestion.通过颗粒计数免疫测定结合胃蛋白酶消化对各种人体分泌物中IgE水平的重新评估。
Int Arch Allergy Appl Immunol. 1985;77(3):292-9. doi: 10.1159/000233834.
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The relative paucity of IgE in human milk.人乳中IgE相对缺乏。
J Immunol. 1976 May;116(5):1435-8.
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[Immunologic factors in human colostrum and milk].[人初乳和乳汁中的免疫因素]
Cas Lek Cesk. 1994 May 2;133(9):275-6.
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Immunologic aspects of human colostrum and milk. I. Distribution characteristics and concentrations of immunoglobulins at different times after the onset of lactation.人初乳和乳汁的免疫学特性。I. 泌乳开始后不同时间免疫球蛋白的分布特征和浓度。
J Pediatr. 1978 Apr;92(4):546-9. doi: 10.1016/s0022-3476(78)80285-6.

引用本文的文献

1
Immunological activities of milk.牛奶的免疫活性。
Vet Immunol Immunopathol. 1982 Jan;3(1-2):67-94. doi: 10.1016/0165-2427(82)90032-0.
2
Mucosal immunology.黏膜免疫学
Immunology. 1980 Oct;41(2):249-70.