Muirhead C R
National Radiological Protection Board, Chilton, Didcot, UK.
Cancer Causes Control. 1995 Sep;6(5):383-8. doi: 10.1007/BF00052177.
Following recent research in Great Britain, the geographic incidence of leukemia and non-Hodgkin's lymphoma among White children in three metropolitan regions of the United States (San Francisco-Oakland, CA; Detroit, MI; and Atlanta, GA) during 1978-82 has been analyzed using census tract-specific data. There was no evidence of a general tendency for cases to cluster geographically, in contrast to results from Britain. Further, rates did not vary with median income or education levels for census tracts. However, there was a statistically significant increasing trend in incidence rates with increasing population density: relative risk for highest relative to lowest category = 1.4 (95% percent confidence interval [CI] = 1.1-2.0) for White population density, and 1.4 (CI = 1.0-2.0) for total population density. The interpretation of these findings is unclear and further investigation is required. It is possible that population density is acting as a surrogate for some virus-related factor.
根据英国最近的研究，利用特定普查区的数据对1978 - 1982年期间美国三个大都市地区（加利福尼亚州旧金山 - 奥克兰；密歇根州底特律；佐治亚州亚特兰大）白人儿童中白血病和非霍奇金淋巴瘤的地理发病率进行了分析。与英国的结果相反，没有证据表明病例在地理上有聚集的普遍趋势。此外，普查区的发病率并不随中位数收入或教育水平而变化。然而，发病率随人口密度增加有统计学上显著的上升趋势：白人人口密度最高类别相对于最低类别，相对风险 = 1.4（95%置信区间[CI] = 1.1 - 2.0），总人口密度相对风险为1.4（CI = 1.0 - 2.0）。这些发现的解释尚不清楚，需要进一步调查。有可能人口密度是某些与病毒相关因素的替代指标。
