牙膏中的接触性变应原及其超敏反应综述

Contact allergens in toothpastes and a review of their hypersensitivity.

作者信息

Sainio E L, Kanerva L

机构信息

Product Safety Unit, National Consumer Administration, Helsinki, Finland.

出版信息

Contact Dermatitis. 1995 Aug;33(2):100-5. doi: 10.1111/j.1600-0536.1995.tb00509.x.

DOI:10.1111/j.1600-0536.1995.tb00509.x

PMID:8549124

Abstract

The present study summarizes information on toothpaste composition as supplied by the manufacturers. The survey covered 48 items, virtually all toothpastes offered for sale in Finland. It was concluded that the toothpastes are not entirely safe to use, because almost 50% of the products studied contained a total of some 30 compounds widely recognized as allergens. According to the literature, the most common allergens in toothpastes are flavours (e.g., cinnamic aldehyde, cinnamon oil and peppermint) and preservatives. Symptoms include stomatitis, cheilitis, glossitis, gingivitis, perioral dermatitis and immediate hypersensitivity.

摘要

本研究总结了制造商提供的牙膏成分信息。该调查涵盖了48种产品，几乎包括在芬兰销售的所有牙膏。研究得出结论，这些牙膏使用起来并非完全安全，因为近50%的被研究产品总共含有约30种被广泛认为是过敏原的化合物。根据文献记载，牙膏中最常见的过敏原是香料（如肉桂醛、肉桂油和薄荷）和防腐剂。症状包括口腔炎、唇炎、舌炎、牙龈炎、口周皮炎和速发型超敏反应。