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女性接触木烟与患阻塞性气道疾病的风险

Woodsmoke exposure and risk for obstructive airways disease among women.

作者信息

Dennis R J, Maldonado D, Norman S, Baena E, Martinez G

机构信息

Pontificia Universidad Javeriana, Bogota, Colombia.

出版信息

Chest. 1996 Jan;109(1):115-9. doi: 10.1378/chest.109.1.115.

DOI:10.1378/chest.109.1.115
PMID:8549171
Abstract

OBJECTIVE

To investigate if exposure to firewood smoke and other indoor pollutants is a potential risk factor for obstructive airways disease (OAD) among women in Bogota in whom cigarette smoking and other known risk factors may not be the most frequent.

DESIGN AND SETTING

We conducted a hospital-based case-control study to identify risk factors for OAD among women in Bogota. An interview was conducted using a modified questionnaire recommended by the American Thoracic Society for epidemiologic studies.

PATIENTS

We compared 104 OAD cases with 104 controls matched by hospital and frequency matched by age.

ANALYSIS

The odds ratio (OR) was used as the basic statistic to evaluate risk. Multivariate analysis (MA) was conducted by the Mantel-Haenszel procedure and by logistic regression.

MAIN RESULTS

Univariate analysis showed that tobacco use (OR = 2.22; p < 0.01), wood use for cooking (OR = 3.43; p < 0.001), passive smoking (OR = 2.05; p = 0.01), and gasoline use for cooking (OR = 0.52; p = 0.02) were associated with OAD. Trends for years of tobacco use and years of wood cooking were present (p < 0.05). After MA, variables remained significant except gasoline use.

CONCLUSIONS

This study showed that among elderly women of low socioeconomic status in Bogota, woodsmoke exposure is associated with the development of OAD and may help explain around 50% of all OAD cases. The role of passive smoking remains to be clarified. This work may set the basis for interventional studies in similar settings.

摘要

目的

调查接触柴火烟雾及其他室内污染物是否是波哥大女性患阻塞性气道疾病(OAD)的潜在危险因素,在这些女性中吸烟及其他已知危险因素可能并非最常见。

设计与背景

我们开展了一项基于医院的病例对照研究,以确定波哥大女性患OAD的危险因素。使用美国胸科学会推荐用于流行病学研究的改良问卷进行访谈。

患者

我们将104例OAD病例与104例对照进行比较,对照按医院匹配,年龄按频数匹配。

分析

比值比(OR)用作评估风险的基本统计量。采用Mantel-Haenszel法和逻辑回归进行多变量分析(MA)。

主要结果

单变量分析显示,吸烟(OR = 2.22;p < 0.01)、用木材做饭(OR = 3.43;p < 0.001)、被动吸烟(OR = 2.05;p = 0.01)和用汽油做饭(OR = 0.52;p = 0.02)与OAD相关。存在吸烟年数和用木材做饭年数的趋势(p < 0.05)。多变量分析后,除用汽油做饭外,其他变量仍具有显著性。

结论

本研究表明,在波哥大社会经济地位较低的老年女性中,接触木柴烟雾与OAD的发生有关,可能有助于解释约50%的OAD病例。被动吸烟的作用仍有待阐明。这项工作可为类似环境下的干预研究奠定基础。

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