人类肋骨红骨髓中的脂肪细胞：其大小及相对于氡对造血组织剂量的空间分布。

Fat cells in red bone marrow of human rib: their size and spatial distribution with respect to the radon-derived dose to the haemopoietic tissue.

作者信息

Allen J E, Henshaw D L, Keitch P A, Fews A P, Eatough J P

机构信息

H.H. Wills Physics Laboratory, University of Bristol, UK.

出版信息

Int J Radiat Biol. 1995 Dec;68(6):669-78. doi: 10.1080/09553009514551681.

DOI:10.1080/09553009514551681

PMID:8551110

Abstract

Samples of human rib were collected at autopsy and 20 were selected for marrow fat cell measurement, representing an age range of 16-96 years. The mean diameter of fat cells in red bone marrow of human rib was found to increase from around 48 microns at ages 16-29 years to around 65 microns at ages 82-96 years. There was a greater number of fat cells of smaller size range in younger ages compared with that in older ones. The maximum size of fat cells was found to be 102 microns. Calculated radon-derived doses to haemopoietic tissue ranged from 60 to 162 microSv y-1 at average UK exposures of 20 Bq m-3. It was concluded that the bone marrow fat fraction is the important parameter as far as alpha-radiation dose from radon in fat is concerned. This updates the theoretical estimates of dose carried out by Richardson et al. (1991).

摘要

在尸检时采集了人类肋骨样本，从中选取了20个用于骨髓脂肪细胞测量，年龄范围为16至96岁。发现人类肋骨红骨髓中脂肪细胞的平均直径从16至29岁时的约48微米增加到82至96岁时的约65微米。与年长者相比，年轻者中较小尺寸范围的脂肪细胞数量更多。发现脂肪细胞的最大尺寸为102微米。在英国平均暴露水平为20 Bq m-3的情况下，计算得出的氡对造血组织的剂量范围为60至162微希沃特/年。得出的结论是，就脂肪中氡产生的α辐射剂量而言，骨髓脂肪分数是重要参数。这更新了Richardson等人（1991年）进行的剂量理论估计。