Singh N P, Lai H, Khan A
Department of Psychiatry & Behavioral Sciences, School of Medicine, University of Washington, Seattle 98195-6560, USA. narendra@u. washington.edu
Mutat Res. 1995 Dec;345(3-4):191-6. doi: 10.1016/0165-1218(95)90054-3.
Male Sprague-Dawley rats were intubated with 4 g/kg body weight of ethanol (in a 20%, v/v, water solution). Brain cells were analyzed for single-strand DNA breaks at various post-ethanol administration time points using an alkaline microgel electrophoresis assay. Results showed a significant increase in single-strand DNA breaks in brain cells that peaked at approx. 4 h and returned to control level within 6 h after ethanol administration.
将体重4 g/kg的乙醇（以20%，v/v，水溶液形式）经气管插管给予雄性斯普拉格-道利大鼠。在乙醇给药后的不同时间点，使用碱性微凝胶电泳分析脑细胞的单链DNA断裂情况。结果显示，脑细胞中的单链DNA断裂显著增加，在约4小时达到峰值，并在乙醇给药后6小时内恢复到对照水平。
