Lai H, Singh N P
Bioelectromagnetics Research Laboratory, University of Washington, Seattle 98195, USA.
Bioelectromagnetics. 1997;18(2):156-65.
Acute (2 h) exposure of rats to a 60 Hz magnetic field (flux densities 0.1, 0.25, and 0.5 mT) caused a dose-dependent increase in DNA strand breaks in brain cells of the animals (assayed by a microgel electrophoresis method at 4 h postexposure). An increase in single-strand DNA breaks was observed after exposure to magnetic fields of 0.1, 0.25, and 0.5 mT, whereas an increase in double-strand DNA breaks was observed at 0.25 and 0.5 mT. Because DNA strand breaks may affect cellular functions, lead to carcinogenesis and cell death, and be related to onset of neurodegenerative diseases, our data may have important implications for the possible health effects of exposure to 60 Hz magnetic fields.
将大鼠急性（2小时）暴露于60赫兹磁场（磁通密度分别为0.1、0.25和0.5毫特斯拉）会导致动物脑细胞中的DNA链断裂呈剂量依赖性增加（在暴露后4小时通过微凝胶电泳法测定）。暴露于0.1、0.25和0.5毫特斯拉的磁场后观察到单链DNA断裂增加，而在0.25和0.5毫特斯拉时观察到双链DNA断裂增加。由于DNA链断裂可能影响细胞功能、导致致癌和细胞死亡，并与神经退行性疾病的发病有关，我们的数据可能对暴露于60赫兹磁场可能产生的健康影响具有重要意义。
