Folkard S G, Bianco A E
Liverpool School of Tropical Medicine, UK.
Parasite Immunol. 1995 Jul;17(7):329-33. doi: 10.1111/j.1365-3024.1995.tb00899.x.
The effect of H2 and non-H2 genes in a mouse model of protective immunity against Onchocerca lienalis microfilariae have been investigated. Non-H2 effects were determined using CBA, BALB/c, B10, SJL and TO strains. All were permissive for establishment of a primary infection with microfilariae, although significant differences in parasite recoveries were evident amongst the various strains. The effect of H2 genes upon a primary infection was investigated using H2 congenic B10 and BALB strains, B10, B10.S, B10.BR, B10.D2/n, BALB/c, BALB.B, and BALB.K. Significant H2 effects were seen among the relatively weak responder B10 strains, but were not present among the relatively strong responder BALB strains. These results support a dominant effect of non-H2 genes following primary exposure to microfilariae, and a 'fine tuning' effect of H2 genes that is apparent only in weaker responding strains. Upon reinfection of all the strains investigated, a gradation of protection was detected that appeared to be exclusively dependent upon H2.
已对H2和非H2基因在抗盘尾丝虫微丝蚴保护性免疫小鼠模型中的作用进行了研究。使用CBA、BALB/c、B10、SJL和TO品系确定非H2效应。所有品系都允许微丝蚴建立原发性感染，尽管不同品系之间寄生虫回收率存在显著差异。使用H2同源基因B10和BALB品系、B10、B10.S、B10.BR、B10.D2/n、BALB/c、BALB.B和BALB.K研究了H2基因对原发性感染的影响。在反应相对较弱的B10品系中观察到显著的H2效应，但在反应相对较强的BALB品系中不存在。这些结果支持初次接触微丝蚴后非H2基因的主导作用，以及仅在反应较弱的品系中明显的H2基因“微调”作用。在对所有研究品系进行再感染时，检测到一种似乎完全依赖于H2的保护等级。
