Boos N, Boesch C
Department of Orthopaedic Surgery, Inselspital, University of Bern, Switzerland.
Spine (Phila Pa 1976). 1995 Nov 1;20(21):2358-65; discussion 2366.
Quantitative magnetic resonance imaging (relaxation time and proton density measurements) has gained increasing interest as a noninvasive way to study changes in water content and biochemical composition of lumbar intervertebral discs and vertebral bodies. This article reviews the current methodological problems and the feasibility of quantitative magnetic resonance imaging in the lumbar spine for investigations on water content and biological composition. This technique does not allow direct quantification of water content. Although biochemical variations may sensitively influence relaxation times and proton density under in vitro conditions, it is not feasible to obtain sufficiently reliable and specific information to monitor biochemical alterations associated with lumbar disc pathology in vivo.
定量磁共振成像（弛豫时间和质子密度测量）作为一种研究腰椎间盘和椎体水含量及生化成分变化的非侵入性方法，已引起越来越多的关注。本文综述了当前的方法学问题以及定量磁共振成像在腰椎研究水含量和生物成分方面的可行性。该技术无法直接对水含量进行定量。尽管在体外条件下生化变化可能会灵敏地影响弛豫时间和质子密度，但在体内获得足够可靠且特异的信息以监测与腰椎间盘病变相关的生化改变是不可行的。
