Roberts N, Hogg D, Whitehouse G H, Dangerfield P
Magnetic Resonance and Image Analysis Research Center, University of Liverpool, United Kingdom.
Clin Anat. 1998;11(1):1-8. doi: 10.1002/(SICI)1098-2353(1998)11:1<1::AID-CA1>3.0.CO;2-Z.
The Cavalieri method of modern design stereology has been used in combination with magnetic resonance imaging (MRI) to obtain unbiased estimates of the volume of the lumbar intervertebral discs immediately at the end of a day of normal activity and again following a night's rest. In addition, pixel-by-pixel mapping of the T2-relaxation time has been used to characterize objectively the tissues of the intervertebral discs. The mean increase in height of seven female subjects of average age 21 years (range 19-23 years) measured with a stediometer was 19.3 mm (range 8-26 mm). Image analysis showed that the mean overnight increase in volume of lumbar discs was 1300 mm3 (range 100-2700 mm3). The increase in volume of the disc was accompanied by an increase in the T2-relaxation time of the nucleus pulposus. This suggests that the change in disc volume is most probably caused by a preferential increase in the water content of the nucleus pulposus.
现代设计体视学中的卡瓦列里方法已与磁共振成像（MRI）结合使用，以在正常活动一天结束时以及经过一夜休息后，获得腰椎间盘体积的无偏估计值。此外，T2弛豫时间的逐像素映射已被用于客观地表征椎间盘组织。使用身高计测量的7名平均年龄21岁（范围19 - 23岁）女性受试者的平均身高增加为19.3毫米（范围8 - 26毫米）。图像分析表明，腰椎间盘的平均夜间体积增加为1300立方毫米（范围100 - 2700立方毫米）。椎间盘体积的增加伴随着髓核T2弛豫时间的增加。这表明椎间盘体积的变化很可能是由髓核含水量的优先增加引起的。
