Díaz-Vélez C R, García-Castiñeiras S, Mendoza-Ramos E, Hernández-López E
Department of Internal Medicine, Veterans Administration Hospital, San Juan, Puerto Rico.
Am Heart J. 1996 Jan;131(1):146-52. doi: 10.1016/s0002-8703(96)90063-0.
Malondialdehyde (MDA), a marker of lipid peroxidation, was measured in the plasma of patients with congestive heart failure (CHF) having varying degrees of clinical symptoms and in control subjects. The 53 patients studied were divided in two groups based on their left ventricular ejection fraction (LVEF). Group A consisted of 30 symptomatic patients with chronic CHF (NYHA classes II and III) and LVEF < 40%. Group B consisted of 23 asymptomatic patients with LVEF > 40%. Patients in group A (mean LVEF = 28) has a significantly greater history of myocardial infarction (88% vs 48%; p = 0.002) than those in group B. Group B patients and the controls had similar LVEFs (58.0 vs 62.1; p = 0.14). Neither patients in the CHF group nor group B patients showed correlation between MDA values and LVEF, unless control were included. Mean MDA concentrations in groups A (2.65 +/- 1.03 mumol/L) and B (2.1 +/- 0.7 mumol/L) were significantly higher than those in the control group (1.45 +/- 0.77 mumol/L; p < 0.05), supporting the hypothesis that the CHF state and underlying risk conditions appear to be associate with abnormal oxidative stress. Moreover, a significant correlation (r = 0.74; p = 0.0001) was found in group A patients between the MDA values and the duration in years (chronicity) of the CHF state.
丙二醛（MDA）是脂质过氧化的标志物，在有不同程度临床症状的充血性心力衰竭（CHF）患者及对照组受试者的血浆中进行了测定。所研究的53例患者根据其左心室射血分数（LVEF）分为两组。A组由30例有症状的慢性CHF患者（纽约心脏协会II级和III级）组成，LVEF<40%。B组由23例无症状患者组成，LVEF>40%。A组患者（平均LVEF=28）心肌梗死病史显著多于B组患者（88%对48%；p=0.002）。B组患者和对照组的LVEF相似（58.0对62.1；p=0.14）。除非纳入对照组，CHF组患者和B组患者的MDA值与LVEF之间均未显示出相关性。A组（2.65±1.03μmol/L）和B组（2.1±0.7μmol/L）的平均MDA浓度显著高于对照组（1.45±0.77μmol/L；p<0.05），支持了CHF状态及潜在风险状况似乎与异常氧化应激相关的假说。此外，在A组患者中，MDA值与CHF状态的持续时间（慢性程度）以年计之间存在显著相关性（r=0.74；p=0.0001）。
