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狭窄成形术治疗克罗恩病的安全性如何?

How safe is strictureplasty in the management of Crohn's disease?

作者信息

Ozuner G, Fazio V W, Lavery I C, Church J M, Hull T L

机构信息

Department of Colorectal Surgery A111 Cleveland Clinic Foundation, Ohio 44195, USA.

出版信息

Am J Surg. 1996 Jan;171(1):57-60; discussion 60-1. doi: 10.1016/S0002-9610(99)80074-9.

Abstract

BACKGROUND

Strictureplasty is a well-accepted technique in the management of selected patients with Crohn's disease. To determine the safety and optimal clinical setting for performing strictureplasty, perioperative complications and long-term outcomes need to be analyzed.

PATIENTS AND MATERIALS

We retrospectively reviewed the charts of 162 patients (87 men, 75 women) with Crohn's disease who underwent strictureplasty between June 1984 and July 1994. Medical and surgical history, including medications and laboratory data, intraoperative findings, perioperative complications, and long-term follow-up data were recorded.

RESULTS

These patients underwent 698 strictureplasties (Heineke-Mikulicz procedures, 617; Finney procedures, 81). Median hospital stay was 8 days. Perioperative septic complications were noted in 8 patients (5%); however, reoperation for sepsis was needed only in 5 patients. Five percent of patients developed prolonged ileus after strictureplasty. Symptomatic improvement after strictureplasty was achieved in 98% of patients. Restricture or new stricture or perforative disease was seen in 5% and 17% of patients, respectively, during a 42-month median follow-up period.

CONCLUSIONS

Our findings show that strictureplasty is a good surgical option for stenosing small-bowel Crohn's disease, particularly in patients with multiple obstruction and in those vulnerable to short-bowel syndrome. Perioperative complications are few, and long-term results are gratifying.

摘要

背景

狭窄成形术是治疗特定克罗恩病患者的一种广泛接受的技术。为了确定进行狭窄成形术的安全性和最佳临床环境,需要分析围手术期并发症和长期预后。

患者和材料

我们回顾性分析了1984年6月至1994年7月期间接受狭窄成形术的162例克罗恩病患者(87例男性,75例女性)的病历。记录了患者的内科和外科病史,包括用药情况和实验室数据、术中发现、围手术期并发症以及长期随访数据。

结果

这些患者共接受了698次狭窄成形术(海涅克-米库利兹手术617例,芬尼手术81例)。中位住院时间为8天。8例患者(5%)出现围手术期感染并发症;然而,仅5例患者因败血症需要再次手术。5%的患者在狭窄成形术后出现肠梗阻延长。98%的患者在狭窄成形术后症状得到改善。在中位42个月的随访期内,分别有5%和17%的患者出现狭窄复发或新的狭窄或穿孔性疾病。

结论

我们的研究结果表明,狭窄成形术是治疗狭窄性小肠克罗恩病的一种良好手术选择,特别是对于有多处梗阻的患者以及易患短肠综合征的患者。围手术期并发症较少,长期效果令人满意。

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