Roquelaure Y, Le Gargasson J F, Kupper S, Girre C, Hispard E, Dally S
Clinique toxicologique, Hôpital Fernand Widal, Paris, France.
Alcohol Alcohol. 1995 Sep;30(5):681-5.
Visual contrast sensitivity (VCS) was measured in 30 alcoholic patients and 52 controls. The results showed a significant reduction in VCS for all the spatial frequencies. The mean reduction for all spatial frequencies was 2.49 dB below the level of the control group. Optimal sensitivity corresponded to a lower spatial frequency in patients than controls, i.e. 1 cycle/degree (c/d) versus 2 c/d. Curves for VCS were normal for five patients. Abnormalities in VCS were suggestive of optic nerve dysfunction for 15 patients (50%), which were probable in seven cases (23%) and possible in eight others (27%). For 10 subjects, the abnormalities were indicative of ametropia. Daily alcohol intake and daily tobacco consumption were not significantly different in the patients who displayed VCS abnormalities, reflecting alcohol-tobacco amblyopia, from those who did not. The presence of higher gamma-glutamyl transpeptidase and mean corpuscular volume levels in patients who had VCS abnormalities indicative of alcohol-tobacco amblyopia suggests that alcohol consumption is involved in the development of these abnormalities.
对30名酒精性患者和52名对照者进行了视觉对比敏感度（VCS）测量。结果显示，所有空间频率的VCS均显著降低。所有空间频率的平均降低幅度比对照组低2.49 dB。患者的最佳敏感度对应的空间频率低于对照者，即1周/度（c/d）对2 c/d。5名患者的VCS曲线正常。15名患者（50%）的VCS异常提示视神经功能障碍，其中7例（23%）可能存在视神经功能障碍，另外8例（27%）可能存在。对于10名受试者，异常提示屈光不正。出现VCS异常（反映烟酒性弱视）的患者与未出现异常的患者在每日酒精摄入量和每日烟草消耗量方面无显著差异。出现提示烟酒性弱视的VCS异常的患者中，γ-谷氨酰转肽酶水平较高且平均红细胞体积水平较高，这表明饮酒与这些异常的发生有关。
