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一种快速测定药物进入母乳情况的体外技术。

An in vitro technique for the rapid determination of drug entry into breast milk.

作者信息

Notarianni L J, Belk D, Aird S A, Bennett P N

机构信息

School of Pharmacy, University of Bath.

出版信息

Br J Clin Pharmacol. 1995 Oct;40(4):333-7. doi: 10.1111/j.1365-2125.1995.tb04555.x.

DOI:10.1111/j.1365-2125.1995.tb04555.x
PMID:8554935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1365152/
Abstract
  1. A simple in vitro technique that predicts drug transfer into breast milk is described. 2. Drugs of differing physical and chemical characteristics were tested. 3. The technique provides an experimental system for studying plasma to milk transfer with changing milk composition. 4. A mechanism proposing a role of milk proteins in controlling drug entry into milk is discussed.
摘要
  1. 描述了一种预测药物向母乳中转运的简单体外技术。2. 对具有不同物理和化学特性的药物进行了测试。3. 该技术提供了一个实验系统，用于研究随着乳汁成分变化时血浆到乳汁的转运。4. 讨论了一种提出乳蛋白在控制药物进入乳汁中起作用的机制。

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本文引用的文献

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Modelling of the passage of drugs into milk.药物进入乳汁过程的建模。
Pharmacol Ther. 1993 Sep;59(3):301-10. doi: 10.1016/0163-7258(93)90072-l.
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Rapid method for the routine determination of caffeine and its metabolites by high-performance liquid chromatography.高效液相色谱法常规测定咖啡因及其代谢物的快速方法。
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QSAR analysis of drug excretion into human breast milk.药物排泄至人母乳中的定量构效关系分析。
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Factors affecting the milk-to-plasma drug concentration ratio in lactating women: physical interactions with protein and fat.影响哺乳期妇女乳汁与血浆药物浓度比的因素：与蛋白质和脂肪的物理相互作用。
J Pharm Sci. 1987 Mar;76(3):189-93. doi: 10.1002/jps.2600760302.
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Prediction of drug concentrations in human skim milk from plasma protein binding and acid-base characteristics.基于血浆蛋白结合和酸碱特性预测人脱脂乳中的药物浓度。
Br J Clin Pharmacol. 1988 Apr;25(4):495-503. doi: 10.1111/j.1365-2125.1988.tb03334.x.
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Structural, histochemical and biochemical observations on horse milk-fat-globule membranes and casein micelles.对马乳脂肪球膜和酪蛋白胶粒的结构、组织化学及生物化学观察
Histochemistry. 1988;88(3-6):357-65. doi: 10.1007/BF00570295.
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In vivo evaluation in the lactating rabbit of a model for xenobiotic distribution into breast milk.
J Pharmacol Exp Ther. 1988 Mar;244(3):919-24.
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Relationship between human milk lipid-ultrafiltrate and octanol-water partition coefficients.人乳脂质超滤液与正辛醇-水分配系数之间的关系。
J Pharm Sci. 1988 Sep;77(9):796-8. doi: 10.1002/jps.2600770916.
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Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: results of an in vitro evaluation.
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