恶性疟患者血浆中可溶性细胞间黏附分子-1和E-选择素水平及其与肿瘤坏死因子α、白细胞介素1α（IL-1α）和IL-10水平缺乏相关性
Soluble intercellular adhesion molecule-1 and E-selectin levels in plasma of falciparum malaria patients and their lack of correlation with levels of tumor necrosis factor alpha, interleukin 1 alpha (IL-1 alpha), and IL-10.
作者信息
Peyron F, Caux-Menetrier C, Roux-Lombard P, Niyongabo T, Aubry P, Deloron P
机构信息
Parasitology Laboratory, Claude Bernard University, Lyon, France.
出版信息
Clin Diagn Lab Immunol. 1994 Nov;1(6):741-3. doi: 10.1128/cdli.1.6.741-743.1994.
Abstract
Intercellular adhesion molecule-1 and E-selectin levels were increased in the plasma of 60 falciparum malaria patients and were not related to levels of tumor necrosis factor alpha, interleukin 10, or interleukin 1 alpha. Soluble E-selectin was correlated to disease; its level in plasma was related to levels of both tumor necrosis factor soluble receptors and biological markers of disease severity and returned to baseline after parasite clearance faster than that of soluble intercellular adhesion molecule-1.
摘要
60例恶性疟患者血浆中细胞间黏附分子-1和E-选择素水平升高，且与肿瘤坏死因子α、白细胞介素10或白细胞介素1α水平无关。可溶性E-选择素与疾病相关；其血浆水平与肿瘤坏死因子可溶性受体水平及疾病严重程度的生物学标志物均有关，且在寄生虫清除后恢复至基线水平的速度比可溶性细胞间黏附分子-1更快。
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