人类炎性滑液中的可溶性肿瘤坏死因子受体
Soluble tumor necrosis factor receptors in human inflammatory synovial fluids.
作者信息
Roux-Lombard P, Punzi L, Hasler F, Bas S, Todesco S, Gallati H, Guerne P A, Dayer J M
机构信息
Division of Immunology, University Hospital, Geneva, Switzerland.
出版信息
Arthritis Rheum. 1993 Apr;36(4):485-9. doi: 10.1002/art.1780360408.
OBJECTIVE
To test synovial fluid (SF) for the presence of soluble fragments originating from distinct tumor necrosis factor receptors (TNF-sR55 and TNF-sR75) which bind to TNF and inhibit its biologic activity.
METHODS
TNF-sR55 and TNF-sR75 were measured in 62 SF samples by specific immunoassays using monoclonal antibodies.
RESULTS
Both TNF-sR were present in all of the SF tested. Their concentrations were higher in SF from patients with seropositive rheumatoid arthritis than in patients with other inflammatory arthritides. The relative amount of TNF-sR75, as compared with TNF-sR55, was higher in seropositive RA SF than in other SF.
CONCLUSION
The balance between TNF and its specific inhibitors may be critical to the biologic outcome mediated by this cytokine.
目的
检测滑膜液（SF）中是否存在源自不同肿瘤坏死因子受体（TNF-sR55和TNF-sR75）的可溶性片段，这些受体可结合TNF并抑制其生物活性。
方法
采用单克隆抗体特异性免疫分析法检测62份滑膜液样本中的TNF-sR55和TNF-sR75。
结果
所有检测的滑膜液中均存在这两种TNF-sR。血清阳性类风湿性关节炎患者的滑膜液中其浓度高于其他炎性关节炎患者。与TNF-sR55相比，血清阳性类风湿性关节炎滑膜液中TNF-sR75的相对含量高于其他滑膜液。
结论
TNF与其特异性抑制剂之间的平衡对于该细胞因子介导的生物学结果可能至关重要。
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