Luczynska C M, Griffin P, Davies R J, Topping M D
Immunology Section, Occupational Medicine & Hygiene Laboratories, London, U.K.
Clin Exp Allergy. 1990 Jul;20(4):403-6. doi: 10.1111/j.1365-2222.1990.tb02801.x.
The role of pyroglyphid mites in house dust allergy is well established and the major allergens from the common house dust mites (Dermatophagoides species) have been characterized. There is, however, relatively little progress in the understanding of the human IgE response to non-pyroglyphid storage mites, allergenic crossreactivity with other mite species and extent of environmental exposure. We studied 196 individuals from an urban environment who were not occupationally exposed to storage mites and found a 24% prevalence of specific IgE antibody to Dermatophagoides pteronyssinus and a 14% prevalence of RAST positivity to at least one of three storage mites, Acarus siro, Lepidoglyphus destructor and Tyrophagus longior. All individuals with a positive RAST to storage mites had specific IgE to D. pteronyssinus. RAST inhibition studies with the eight sera with greater than 2% RAST binding to both families of mites showed considerable crossreactivity between D. pteronyssinus and the storage mites A. siro and T. longior and limited crossreactivity between D. pteronyssinus and L. destructor. This suggests that at least some of the response to storage mites observed by direct RAST is a consequence of crossreactivity with the more abundant D. pteronyssinus.
粉尘螨在屋尘过敏中的作用已得到充分证实，常见屋尘螨（粉尘螨属）的主要过敏原也已得到鉴定。然而，在了解人类对非粉尘螨类仓储螨的IgE反应、与其他螨类的过敏原交叉反应以及环境暴露程度方面，进展相对较少。我们研究了196名来自城市环境、未职业性接触仓储螨的个体，发现对尘螨的特异性IgE抗体患病率为24%，对三种仓储螨（腐食酪螨、害嗜鳞螨和粗脚粉螨）中至少一种的RAST阳性率为14%。所有对仓储螨RAST阳性的个体均对尘螨有特异性IgE。对螨类两个家族RAST结合率均大于2%的8份血清进行的RAST抑制研究表明，尘螨与仓储螨腐食酪螨和粗脚粉螨之间存在相当程度的交叉反应，而尘螨与害嗜鳞螨之间的交叉反应有限。这表明，通过直接RAST观察到的对仓储螨的至少部分反应是与更常见的尘螨交叉反应的结果。
