金黄色葡萄球菌中的大环内酯类耐药性：大环内酯类耐药性的诱导因素。
Macrolide resistance in Staphylococcus aureus: inducers of macrolide resistance.
作者信息
Allen N E
出版信息
Antimicrob Agents Chemother. 1977 Apr;11(4):669-74. doi: 10.1128/AAC.11.4.669.
Abstract
Several macrolide-, lincosamide-, and streptogramin B-type (MLS) antibiotics were tested as inducers of erythromycin A (EM)-resistant [(14)C]leucine incorporation. Only 14-membered-ring macrolides having a glycosidically linked 6-deoxy sugar at the C-3 position of the lactone ring and the structurally dissimilar lincosamide, celesticetin, showed inducer activity. Modifications of EM at the C-4'' position of cladinose can apparently destroy the inducer property but do not affect the inhibitory properties of the antibiotic. The findings clearly show that inducer and inhibitor activities can be dissociated and are consistent with the concept that distinct binding/receptor sites are utilized for inhibition of ribosome function and induction of resistance.
摘要
测试了几种大环内酯类、林可酰胺类和链阳菌素B型（MLS）抗生素作为红霉素A（EM）抗性[(14)C]亮氨酸掺入诱导剂的情况。只有在内酯环C-3位具有糖苷键连接的6-脱氧糖的14元环大环内酯类以及结构不同的林可酰胺类药物天青菌素显示出诱导活性。在克拉定糖的C-4''位对EM进行修饰显然会破坏诱导特性，但不影响抗生素的抑制特性。这些发现清楚地表明诱导剂和抑制剂活性可以分离，并且与利用不同的结合/受体位点来抑制核糖体功能和诱导抗性的概念一致。
相似文献
1
Macrolide resistance in Staphylococcus aureus: inducers of macrolide resistance.金黄色葡萄球菌中的大环内酯类耐药性：大环内酯类耐药性的诱导因素。
Antimicrob Agents Chemother. 1977 Apr;11(4):669-74. doi: 10.1128/AAC.11.4.669.
2
[Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus].金黄色葡萄球菌对大环内酯类、林可酰胺类及链阳菌素B类抗生素耐药性的研究
Yakugaku Zasshi. 2000 Apr;120(4):374-86. doi: 10.1248/yakushi1947.120.4_374.
3
Inducible resistance to a 16-membered macrolide, mycinamicin, in Staphylococcus aureus resistant to 14-membered macrolides and streptogramin B antibiotics.对14元大环内酯类和链阳菌素B抗生素耐药的金黄色葡萄球菌中，对16元大环内酯类抗生素麦迪霉素的诱导性耐药。
J Pharmacobiodyn. 1992 Jun;15(6):319-24. doi: 10.1248/bpb1978.15.319.
4
[A quantitative determination of inducibility by 14 membered ring macrolide antibiotics in inducible resistant Staphylococcus aureus to macrolide-lincosamide-streptogramin B antibiotics].[对诱导性耐大环内酯-林可酰胺-链阳菌素B类抗生素的金黄色葡萄球菌中14元环大环内酯类抗生素诱导性的定量测定]
Yakugaku Zasshi. 1994 Dec;114(12):1015-20. doi: 10.1248/yakushi1947.114.12_1015.
5
Macrolide-lincosamide-streptogramin B resistance phenotypes and genotypes among Staphylococcus aureus clinical isolates in Japan.日本金黄色葡萄球菌临床分离株中对大环内酯-林可酰胺-链阳菌素B的耐药表型和基因型
Clin Microbiol Infect. 2007 Mar;13(3):325-7. doi: 10.1111/j.1469-0691.2006.01632.x.
6
New macrolides active against Streptococcus pyogenes with inducible or constitutive type of macrolide-lincosamide-streptogramin B resistance.对具有诱导型或组成型大环内酯-林可酰胺-链阳菌素B耐药性的化脓性链球菌有效的新型大环内酯类药物。
Antimicrob Agents Chemother. 1989 Jan;33(1):78-81. doi: 10.1128/AAC.33.1.78.
7
Susceptibility of methicillin-resistant Staphylococcus aureus clinical isolates to various antimicrobial agents. III. Novel, inducible resistance to macrolide-lincosamide-streptogramin B (MLS) antibiotics.耐甲氧西林金黄色葡萄球菌临床分离株对多种抗菌药物的敏感性。III. 对大环内酯-林可酰胺-链阳菌素B（MLS）抗生素的新型诱导性耐药
Hiroshima J Med Sci. 1993 Sep;42(3):101-7.
8
Macrolide resistance in Staphylococcus aureus: induction of macrolide-resistant protein synthesis.金黄色葡萄球菌中的大环内酯耐药性：大环内酯耐药蛋白合成的诱导
Antimicrob Agents Chemother. 1977 Apr;11(4):661-8. doi: 10.1128/AAC.11.4.661.
9
10
Ketolides lack inducibility properties of MLS(B) resistance phenotype.酮内酯类药物缺乏MLS(B)耐药表型的诱导性。
J Antimicrob Chemother. 1997 Jul;40(1):85-90. doi: 10.1093/jac/40.1.85.
引用本文的文献
1
Trend determination of methicillin-resistant infections with statistical modeling.运用统计建模确定耐甲氧西林感染的趋势
North Clin Istanb. 2025 Feb 3;12(1):12-20. doi: 10.14744/nci.2023.66891. eCollection 2025.
2
Metagenomic insights into dissemination of antibiotic resistance across bacterial genera in wastewater treatment.宏基因组学揭示了污水处理厂中细菌属间抗生素耐药性的传播。
Chemosphere. 2021 May;271:129563. doi: 10.1016/j.chemosphere.2021.129563. Epub 2021 Jan 7.
3
Ribosome-Mediated Attenuation of (A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants.核糖体介导的(A)表达衰减受 Vga(A)蛋白变体对抗生素耐药性特异性的影响。
Antimicrob Agents Chemother. 2020 Oct 20;64(11). doi: 10.1128/AAC.00666-20.
4
Development of macrolide resistance in Bordetella bronchiseptica is associated with the loss of virulence.支气管败血波氏杆菌大环内酯类耐药的发展与其毒力丧失有关。
J Antimicrob Chemother. 2018 Oct 1;73(10):2797-2805. doi: 10.1093/jac/dky264.
5
Natural Products as Platforms To Overcome Antibiotic Resistance.作为克服抗生素耐药性平台的天然产物
Chem Rev. 2017 Oct 11;117(19):12415-12474. doi: 10.1021/acs.chemrev.7b00283. Epub 2017 Sep 27.
6
Constitutive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter.弯曲杆菌中rRNA甲基化酶基因erm(B)的组成型和诱导型表达
Antimicrob Agents Chemother. 2015 Oct;59(10):6661-4. doi: 10.1128/AAC.01103-15. Epub 2015 Aug 10.
7
Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain.含芳基四唑链的酰化物衍生物的合成及其抗菌活性
Drug Des Devel Ther. 2014 Sep 24;8:1515-25. doi: 10.2147/DDDT.S65673. eCollection 2014.
8
The evolving role of chemical synthesis in antibacterial drug discovery.化学合成在抗菌药物发现中不断演变的作用。
Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8840-69. doi: 10.1002/anie.201310843. Epub 2014 Jul 2.
9
Direct entry to erythronolides via a cyclic bis[allene].通过环状双[烯丙基]直接进入 erythronolide 途径。
J Am Chem Soc. 2011 Sep 28;133(38):14968-71. doi: 10.1021/ja207496p. Epub 2011 Sep 6.
10
Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.抗生素配体在新生肽依赖性核糖体停滞中的作用。
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10496-501. doi: 10.1073/pnas.1103474108. Epub 2011 Jun 13.
本文引用的文献
1
INDUCIBLE RESISTANCE TO ERYTHROMYCIN IN STAPHYLOCOCCUS AUREUS.金黄色葡萄球菌对红霉素的诱导抗性
J Bacteriol. 1964 Sep;88(3):574-80. doi: 10.1128/jb.88.3.574-580.1964.
2
The specificity of lincomycin binding to ribosomes.林可霉素与核糖体结合的特异性。
Biochemistry. 1967 Mar;6(3):836-43. doi: 10.1021/bi00855a025.
3
Erythromycin-inducible resistance in Staphylococcus aureus: survey of antibiotic classes involved.金黄色葡萄球菌中红霉素诱导的耐药性：涉及抗生素类别的调查
J Bacteriol. 1969 May;98(2):447-52. doi: 10.1128/jb.98.2.447-452.1969.
4
Macrolide resistance in Staphylococcus aureus. Isolation of a mutant in which leucomycin is an active inducer.
Jpn J Microbiol. 1970 Nov;14(6):473-8.
5
6
Studies on the antibiotics from Streptomyces spinichromogenes var. kujimyceticus. V. Some antimicrobial characteristics of kujimycin A and kujimycin B against macrolide resistant staphylococci.
J Antibiot (Tokyo). 1970 Sep;23(9):448-60. doi: 10.7164/antibiotics.23.448.
7
Genetics of resistance to macrolide antibiotics and lincomycin in natural isolates of Streptococcus pyogenes.化脓性链球菌自然分离株对大环内酯类抗生素和林可霉素耐药性的遗传学研究
Mol Gen Genet. 1974;135(4):349-67. doi: 10.1007/BF00271149.
8
Inducible and constitutive resistance to macrolide antibiotics and lincomycin in clinically isolated strains of Streptococcus pyogenes.化脓性链球菌临床分离株对大环内酯类抗生素和林可霉素的诱导性及固有耐药性
Antimicrob Agents Chemother. 1973 Sep;4(3):327-31. doi: 10.1128/AAC.4.3.327.
9
Mutant of Staphylococcus aureus with lincomycin- and carbomycin-inducible resistance to erythromycin.对林可霉素和碳霉素诱导的红霉素耐药的金黄色葡萄球菌突变体。
Antimicrob Agents Chemother. 1974 May;5(5):538-40. doi: 10.1128/AAC.5.5.538.
10
Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction.金黄色葡萄球菌中红霉素诱导性耐药：诱导的条件
J Bacteriol. 1971 Jun;106(3):835-47. doi: 10.1128/jb.106.3.835-847.1971.
Zotero 插件