Ward A C, de Koning-Ward T F
Biomolecular Research Institute, Parkville, Victoria, Australia.
Virus Genes. 1995;10(2):179-83. doi: 10.1007/BF01702599.
The neurovirulent strain of influenza A virus, A/NWS/33, is able to infect a large range of cell types, including mouse brain cells, which are not infected by its parent, A/WS/33. This seems to be largely due to the hemagglutinin of A/NWS/33. The complete nucleotide sequence of the HA genes of both strains has been determined and a comparison revealed a number of changes. Analysis showed that the virulence capabilities of the NWS HA involve at least three different mechanisms: (a) loss of a glycosylation site; (b) a change at the cleavage site; and (c) a substitution in HA2, which may increase the pH of fusion.
甲型流感病毒的神经毒株A/NWS/33能够感染多种细胞类型，包括小鼠脑细胞，而其亲代毒株A/WS/33则不能感染这些细胞。这似乎主要归因于A/NWS/33的血凝素。已确定了这两种毒株HA基因的完整核苷酸序列，比较结果显示存在一些变化。分析表明，NWS HA的致病能力至少涉及三种不同机制：（a）一个糖基化位点的缺失；（b）裂解位点的变化；以及（c）HA2中的一个替代，这可能会提高融合的pH值。
