[儿茶酚胺能系统受损会导致大鼠早期行为反应形成的减慢]

[Damage to the catecholaminergic system causes a slowing in the formation of early behavioral reactions in rats].

作者信息

Podkletnova I M, Alkho Kh E

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Sep-Oct;45(5):1023-8.

Abstract

Influence of 6-hydroxydopamine (6-OHDA) on catecholaminergic brain system and development of early behavioural patterns was studied in 1-20-days-old Wistar rats. After 6-OHDA neonatal injection the number on catecholaminergic terminals in deep layers of pons-medulla was considerably reduced while the number of catecholaminergic neurons was 2-3 times increased. Damage of catecholaminergic innervation of the forebrain of rats was shown to cause a delay in development of washing behaviour, searching activity and disturbance of orientation in new environment.

摘要

在1至20日龄的Wistar大鼠中研究了6-羟基多巴胺（6-OHDA）对儿茶酚胺能脑系统及早期行为模式发育的影响。新生大鼠注射6-OHDA后，脑桥-延髓深层儿茶酚胺能终末数量显著减少，而儿茶酚胺能神经元数量增加了2至3倍。结果表明，大鼠前脑儿茶酚胺能神经支配受损会导致梳理行为、探索活动发育延迟以及在新环境中定向障碍。

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