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暴发性肺栓塞的改良手术理念。

Modified surgical concept for fulminant pulmonary embolism.

作者信息

Jakob H, Vahl C, Lange R, Micek M, Tanzeem A, Hagl S

机构信息

Department of Cardiac Surgery, Ruprecht-Karls-Universität, Heidelberg, Germany.

出版信息

Eur J Cardiothorac Surg. 1995;9(10):557-60; discussion 561. doi: 10.1016/s1010-7940(05)80005-3.

Abstract

Surgical intervention in fulminant pulmonary embolism (PE) is still associated with an overall 30% fatal outcome which increases to about 60% when cardiopulmonary resuscitation (CPR) is necessary. Despite unfavorable conditions like hemodynamic instability, failed lysis or CPR, the surgical strategy might have a certain impact on the patient's outcome since 30-40% of the surgical mortality is related to persistent right heart failure and early thromboembolic recurrence. From 1/88 to 8/94 a total of 25 patients (15 females, 10 men, mean age 57 [25-78]) years underwent emergency pulmonary embolectomy with the use of the heart-lung machine. Seventeen patients were operated upon between 1988 and 1992. A standard approach by central pulmonary artery incision with extraction of adjacent pulmonary emboli using forceps, suction of Fogarty catheters was used. Six of these patients (35%) died, with four out of six operated upon under CPR. Since 1993 we have used a modified surgical strategy in eight patients. Five patients (63%) were operated on after or under CPR. In these cases, left and right pulmonary arteries were incised peripherally and all segmental arteries were desobliterated selectively using small suction devices. Thereafter the right atrium was opened and inspected. After removal of the inferior caval vein cannula all inferior body blood was taken with cardiotomy suction while both legs and the abdomen were massaged centripetally to mobilize additional fresh thrombotic material. In three cases up to 50 cm long thrombi could be delivered. All patients have survived to date with two patients receiving a LGM caval filter placed percutaneously after bilateral postoperative phlebography had revealed ongoing thrombotic disease. We conclude that selective desobliteration of every segmental pulmonary artery in combination with simultaneous clearance of major body veins from additional thrombotic material will probably lower surgical mortality in these critically ill patients.

摘要

暴发性肺栓塞(PE)的外科干预总体死亡率仍达30%,若需进行心肺复苏(CPR),则死亡率升至约60%。尽管存在血流动力学不稳定、溶栓失败或需进行心肺复苏等不利情况,但手术策略可能对患者预后有一定影响,因为30 - 40%的手术死亡率与持续性右心衰竭和早期血栓栓塞复发有关。1988年1月至1994年8月,共有25例患者(15例女性,10例男性,平均年龄57[25 - 78]岁)使用心肺机进行了急诊肺栓子切除术。1988年至1992年间对17例患者进行了手术。采用经中央肺动脉切口的标准方法,用镊子取出相邻肺栓子,并用Fogarty导管抽吸。其中6例患者(35%)死亡,6例中有4例在心肺复苏下进行手术。自1993年以来,我们对8例患者采用了改良的手术策略。5例患者(63%)在心肺复苏后或在心肺复苏下进行手术。在这些病例中,左右肺动脉在外周切开,使用小型抽吸装置选择性地清除所有节段性动脉内的栓子。此后打开右心房并进行检查。拔除下腔静脉插管后,用心脏切开吸引器抽吸所有下半身血液,同时双腿和腹部向心性按摩以促使更多新鲜血栓物质移动。在3例病例中,可取出长达50厘米的血栓。所有患者至今均存活,2例患者在术后双侧静脉造影显示仍有血栓形成疾病后,经皮放置了LGM腔静脉滤器。我们得出结论,对每个节段性肺动脉进行选择性栓子清除并同时清除主要体静脉内的额外血栓物质,可能会降低这些重症患者的手术死亡率。

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