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磁场与儿童癌症——两项斯堪的纳维亚研究的汇总分析

Magnetic fields and childhood cancer--a pooled analysis of two Scandinavian studies.

作者信息

Feychting M, Schulgen G, Olsen J H, Ahlbom A

机构信息

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

出版信息

Eur J Cancer. 1995 Nov;31A(12):2035-9. doi: 10.1016/0959-8049(95)00472-6.

Abstract

To test the hypothesis that exposure to magnetic fields, of the type generated by high voltage installations, increases cancer incidence in children, the original data from two case-control studies were pooled. The Swedish study was based on children living within 300 m from transmission lines, and the Danish study on the total population of Denmark. In both these studies, national cancer registries were used to identify cases of leukaemia, lymphoma or central nervous system tumour. Controls were selected randomly from the study populations. Magnetic field exposure was assessed through theoretical calculations of the magnetic fields before the time of diagnosis. An elevated relative risk of childhood leukaemia was found for calculated magnetic field levels of > or = 0.2 microT, estimated at 2.0 (95% CI 1.0-4.1), and for magnetic field levels of > or = 0.5 microT, estimated at 5.1 (95% CI 2.1-12.6). The results support the hypothesis of an association between magnetic fields and childhood leukaemia.

摘要

为了验证暴露于高压设施产生的那种磁场会增加儿童癌症发病率这一假设,两项病例对照研究的原始数据被汇总。瑞典的研究基于居住在距输电线路300米范围内的儿童,丹麦的研究基于丹麦全体人口。在这两项研究中,国家癌症登记处被用于识别白血病、淋巴瘤或中枢神经系统肿瘤病例。对照是从研究人群中随机选取的。磁场暴露是通过在诊断前对磁场进行理论计算来评估的。对于计算得出的磁场水平≥0.2微特斯拉,估计相对风险升高,为2.0(95%可信区间1.0 - 4.1);对于磁场水平≥0.5微特斯拉,估计相对风险为5.1(95%可信区间2.1 - 12.6)。结果支持了磁场与儿童白血病之间存在关联的假设。

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