Hekking M, Lindemans J, Gelsema E S
Department of Medical Informatics, Erasmus University, Rotterdam, The Netherlands.
Proc Annu Symp Comput Appl Med Care. 1995:52-6.
Monitoring the arterial acid-base status of ICU patients is done by measuring and calculating the acid-base variables pH, the partial pressure of carbon-dioxide (PCO2) and the bicarbonate-ion concentration ([HCO-3]). Univariate normal reference ranges exist for these values. However, it is well known that an exact linear relationship exists between pH, the logarithm of PCO2 and the logarithm of [HCO-3] values. We developed a computer program for the multivariate evaluation and graphical monitoring of these values in an intensive care setting that takes this intrinsic two-dimensionality into account. A composite index is introduced for the monitoring of all three laboratory values. Moreover, using this index, a multivariate statistical reference region based on an unselected population of ICU patients was derived.
监测重症监护病房(ICU)患者的动脉酸碱状态是通过测量和计算酸碱变量pH、二氧化碳分压(PCO2)和碳酸氢根离子浓度([HCO-3])来完成的。这些值存在单变量正常参考范围。然而,众所周知,pH、PCO2的对数和[HCO-3]值的对数之间存在精确的线性关系。我们开发了一个计算机程序,用于在重症监护环境中对这些值进行多变量评估和图形监测,该程序考虑了这种内在的二维性。引入了一个综合指数来监测所有三个实验室值。此外,使用该指数,基于未选择的ICU患者群体得出了一个多变量统计参考区域。