Gereben B, Gerics B, Gálfi P, Rudas P, Hajós F, Jancsik V
Department of Physiology and Biochemistry, University of Veterinary Science, Budapest, Hungary.
Neurobiology (Bp). 1995;3(2):151-64.
Two monoclonal antibodies directed against vimentin, Vim 3B4 and V9 could distinguish between vimentins originating from certain species, when tested on cell lines (Bohn et al, 1992). Our comparative immunohistochemical studies in the rat and chicken brain with the same antibodies suggest the coexistence of two vimentin forms in the glial cells of both species. One of these forms bearing the epitope present in the respective non-glial cell lines is present in astrocytes and Bergmann glia independently of the ontogenic state of the animal. The other epitope appeared also mutually in both species, albeit its expression was more restricted. These patterns suggest that in these two species, the expression of the different vimentin forms might be differently regulated.
两种针对波形蛋白的单克隆抗体Vim 3B4和V9，在细胞系上进行测试时，能够区分来自某些物种的波形蛋白（博恩等人，1992年）。我们使用相同抗体对大鼠和鸡脑进行的比较免疫组织化学研究表明，这两个物种的神经胶质细胞中存在两种波形蛋白形式。其中一种带有各自非神经胶质细胞系中存在的表位的波形蛋白形式，独立于动物的个体发育状态，存在于星形胶质细胞和伯格曼胶质细胞中。另一种表位在两个物种中也相互出现，尽管其表达更受限制。这些模式表明，在这两个物种中，不同波形蛋白形式的表达可能受到不同的调节。
